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S8751

磺胺胍

别名:

4-氨基-N-(氨基亚氨基甲基)苯磺酰胺, 4-氨基-N-胍基苯磺酰胺

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关于此项目

经验公式（希尔记法）:
C7H10N4O2S
化学文摘社编号:
57-67-0
分子量:
214.24
UNSPSC Code:
51283914
NACRES:
NA.85
PubChem Substance ID:
24899810
EC Number:
200-345-9
Beilstein/REAXYS Number:
2695326
MDL number:
MFCD00038136
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biological source

synthetic (Organic)

Quality Level

200

form

powder

color

white to off-white

solubility

1 M HCl: soluble 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

SMILES string

NC(=N)NS(=O)(=O)c1ccc(N)cc1

InChI

1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)

InChI key

BRBKOPJOKNSWSG-UHFFFAOYSA-N

Gene Information

human ... F2(2147), PRSS1(5644)

General description

化学结构：磺胺

Application

磺胺胍被用来阻止叶酸的合成。可用于研究其对微孢子生长和宿主细胞活力的影响。

Biochem/physiol Actions

磺胺胍是一种磺胺类抗生素。磺酰胺可通过抑制二氢蝶呤合酶来阻止二氢叶酸的合成。磺胺类药物是细菌对氨基苯甲酸（PABA；细菌中叶酸合成所必需）的竞争性抑制剂。磺胺胍是一种二氢叶酸还原酶（DHFR）的抑制剂。磺胺类药物对革兰氏阳性细菌和革兰氏阴性细菌具有活性。抗性模式是通过二氢蝶呤合酶的改变或叶酸合成的替代途径。

Other Notes

将容器密闭保存在干燥和通风良好的地方。在干燥处保存。储存类别 (TRGS 510)：非易燃固体

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000491940
0000491940
0000489845
0000489845
SLCP5182

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B W Clare et al.
Journal of enzyme inhibition, 16(1), 1-13 (2001-08-11)
A series of compounds has been prepared by reaction of dicyandiamide with alkyl/arylsulfonyl halides as well as arylsulfonylisocyanates to locate a lead for obtaining weakly basic thrombin inhibitors with sulfonyldicyandiamide moieties as the S1 anchoring group. The detected lead was
Vimal K Balakrishnan et al.
Journal of chromatography. A, 1131(1-2), 1-10 (2006-08-02)
In recent years, pharmaceutical and personal care products (PPCPs) have been detected in diverse environments (including groundwater, river water, and municipal wastewater). In order to evaluate their environmental impact, PPCPs must first be accurately determined. In this study, we focused
B Beauvais et al.
Antimicrobial agents and chemotherapy, 38(10), 2440-2448 (1994-10-01)
We have developed a new micromethod to study the effect of drugs on microsporidia, using MRC5 fibroblasts infected by 10(5) spores of Encephalitozoon cuniculi. After 3 days of incubation with various concentrations of drugs, parasitic foci were counted in stained
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全球贸易项目编号

货号GTIN
S8751-100G04061833613566
S8751-25G04061833512937
S8751-500G04061833624555