S8753
马钱子碱 盐酸盐
glycine receptor antagonist
产品名称
马钱子碱 盐酸盐,
SMILES字符串
Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]
InChI
1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1
InChI key
VLXYTKMPCOQKEM-ZEYGOCRCSA-N
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应用
Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.
生化/生理作用
惊厥剂；与 NMDA 受体无关的甘氨酸受体拮抗剂。
Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity
Bhati R, et al.
Journal of Ayurveda and integrative medicine, 3(2), 80-80 (2012)
Biomarkers in Toxicology null
Daniel S Borrus et al.
eNeuro, 7(3) (2020-05-13)
The preBötzinger complex (preBötC) gives rise to two types of breathing behavior under normal physiological conditions: eupnea and sighing. Here, we examine the neural mechanisms that couple their underlying rhythms. We measured breathing in awake intact adult mice and recorded
Direct activation of the Mauthner cell by electric field pulses drives ultrarapid escape responses
Tabor KM, et al.
Journal of Neurophysiology, 112(4), 834-844 (2014)
Shankai Yin et al.
Hearing research, 237(1-2), 32-48 (2008-02-08)
Neural tuning to sound durations is a useful filter for the identification of a variety of sounds. Previous studies have shown that the interaction between excitatory and inhibitory inputs plays a role in duration selectivity in echolocating bats. However, this
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