S8753
马钱子碱 盐酸盐
glycine receptor antagonist
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关于此项目
经验公式（希尔记法）:
C21H22N2O2 · HCl
化学文摘社编号:
分子量:
370.87
EC 号:
MDL编号:
UNSPSC代码:
12352210
PubChem化学物质编号:
NACRES:
NA.32
产品名称
马钱子碱 盐酸盐,
质量水平
SMILES字符串
Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]
InChI
1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1
InChI key
VLXYTKMPCOQKEM-ZEYGOCRCSA-N
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应用
Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.
生化/生理作用
惊厥剂；与 NMDA 受体无关的甘氨酸受体拮抗剂。
Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
Horizontal cell feedback without cone type-selective inhibition mediates red?green color opponency in midget ganglion cells of the primate retina
Crook JD, et al.
The Journal of Neuroscience, 31(5), 1762-1772 (2011)
Biomarkers in Toxicology null
Y-cell receptive field and collicular projection of parasol ganglion cells in macaque monkey retina
Crook JD, et al.
The Journal of Neuroscience, 28(44), 11277-11291 (2008)
Direct activation of the Mauthner cell by electric field pulses drives ultrarapid escape responses
Tabor KM, et al.
Journal of Neurophysiology, 112(4), 834-844 (2014)
Effect of Strychinine, a Glycine Inhibitor, on the Programmed Cell Death of Motoneurons during the Chick Development.
Kim JY
Experimental Neurobiology, 20(4), 176-180 (2011)
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