S8753
马钱子碱 盐酸盐
glycine receptor antagonist
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关于此项目
经验公式（希尔记法）:
C21H22N2O2 · HCl
化学文摘社编号:
分子量:
370.87
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352210
EC Number:
215-826-9
MDL number:
产品名称
马钱子碱 盐酸盐,
InChI key
VLXYTKMPCOQKEM-ZEYGOCRCSA-N
InChI
1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1
SMILES string
Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]
Quality Level
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Biochem/physiol Actions
惊厥剂；与 NMDA 受体无关的甘氨酸受体拮抗剂。
Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.
Application
Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity
Bhati R, et al.
Journal of Ayurveda and integrative medicine, 3(2), 80-80 (2012)
Y-cell receptive field and collicular projection of parasol ganglion cells in macaque monkey retina
Crook JD, et al.
The Journal of Neuroscience, 28(44), 11277-11291 (2008)
Direct activation of the Mauthner cell by electric field pulses drives ultrarapid escape responses
Tabor KM, et al.
Journal of Neurophysiology, 112(4), 834-844 (2014)
Shankai Yin et al.
Hearing research, 237(1-2), 32-48 (2008-02-08)
Neural tuning to sound durations is a useful filter for the identification of a variety of sounds. Previous studies have shown that the interaction between excitatory and inhibitory inputs plays a role in duration selectivity in echolocating bats. However, this
Effect of Strychinine, a Glycine Inhibitor, on the Programmed Cell Death of Motoneurons during the Chick Development.
Kim JY
Experimental Neurobiology, 20(4), 176-180 (2011)
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