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S8826

塞马克斯

≥98% (HPLC)

别名:

ACTH (4-7) ，脯氨酸-甘氨酸-脯氨酸 三氟乙酸盐, L-甲硫氨酰-L-a-谷氨酰-L-组氨酰-L-苯丙氨酰-L-脯氨酰甘氨酰-L-脯氨酸 三氟乙酸盐, Met-Glu-His-Phe-Pro-Gly-Pro

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关于此项目

经验公式（希尔记法）:
C37H51N9O10S · xC2HF3O2
化学文摘社编号:
80714-61-0
分子量:
813.92 (free base basis)
NACRES:
NA.32
PubChem Substance ID:
329824612
UNSPSC Code:
51111800
MDL number:
MFCD04113563
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

H2O: >2 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CSCC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N3CCC[C@H]3C(=O)NCC(=O)N4CCC[C@H]4C(O)=O

InChI

1S/C37H51N9O10S.C2HF3O2/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56;3-2(4,5)1(6)7/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56);(H,6,7)/t24-,25-,26-,27-,28-,29-;/m0./s1

InChI key

UAXRUQRHZBYPHF-IGCYJKAMSA-N

General description

Semax 调节海马（脑源性神经营养因子）BDNF/（原肌球蛋白受体激酶 B）trkB 系统的表达和激活。它增强信息接收时的选择性注意，增强记忆巩固和刺激学习能力。Semax 是 Semax 药物的活性成分，用于治疗脑缺氧和缺血。它刺激胆碱乙酰转移酶的活性。Semax 具有黑皮质素 (MC) 受体拮抗剂的属性。

Biochem/physiol Actions

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) 是促肾上腺皮质激素片段的类似物 (4-10)。它激活神经营养因子的转录，具有神经保护和促智活性。
Semax 是一种神经保护 ACTH (4-10) 类似物。

wgk

WGK 3

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000453778
0000453778
0000177129
0000160000
0000160000

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M E Grigorjeva et al.
Bulletin of experimental biology and medicine, 149(1), 44-46 (2010-11-30)
The effects of semax on anticoagulant, fibrinolytic, and platelet components of the anticoagulation system were studied on albino rats under conditions of acute and chronic immobilization stress. Semax exhibited a protective antistress effect after repeated intranasal administration under conditions of
D M Manchenko et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 96(10), 1014-1023 (2011-01-29)
Heptapeptide Semax (MEHFPGP) is the fragment of ACTH(4-10) analogue with prolonged neurotropic activity. The aim of the present work was to study the Semax effects on learning capability and pain sensitivity in white rats following intraperitoneal and intranasal administration in
G A Romanova et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (3)(3), 62-67 (2012-10-18)
It was stated, that with bilateral photochemically induced thrombosis of the prefrontal cortex peptide semax and the AB-Glu by intranasal injection provoke pronounced neuroprotective and antiamnestic action. Intranasal injection semax (250 mkg/kg/daily during six postoperative days) and AB-Glu (250 mkg/kg
Semax prevents functional impairments of avoidance response in rats.
A N Inozemtsev et al.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 448, 1-3 (2013-03-13)
K V Shevchenko et al.
Bioorganicheskaia khimiia, 37(4), 475-482 (2011-11-22)
Proteolysis of semax (Met-Glu-His-Phe-Pro-Gly-Pro, Sem) and its analogues ([Ala1]Sem, [Gly1]Sem, [Thr1]Sem, [Trp1]Sem) that are differ from semax in substitution of N-terminal Met residue were studied. It is shown that such replacement changes the rate of peptides degradation by N-aminopeptidases (EC
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全球贸易项目编号

货号GTIN
S8826-1MG04061826285121

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