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S9318

Sandoz 58-035

Name: Sandoz 58-035
Brand: SIGMA

>98% (HPLC), powder, acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor

别名:

3-[癸基二甲基甲硅烷基] -N- [2-（4-甲基苯基）-1-苯乙基]丙酰胺, SA 58-035

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关于此项目

经验公式（希尔记法）:

C₃₀H₄₇NOSi

化学文摘社编号:

78934-83-5

分子量:

465.79

UNSPSC Code:

41121801

PubChem Substance ID:

24278227

NACRES:

NA.77

MDL number:

MFCD00161339

Assay:

>98% (HPLC)

Form:

powder

Quality level:

100

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产品名称

Sandoz 58-035, >98% (HPLC), powder

Quality Level

100

assay

>98% (HPLC)

form

powder

color

white

solubility

DMSO: 16 mg/mL, H₂O: insoluble

originator

Novartis

storage temp.

2-8°C

SMILES string

CCCCCCCCCC[Si](C)(C)CCC(=O)NC(Cc1ccc(C)cc1)c2ccccc2

InChI

1S/C30H47NOSi/c1-5-6-7-8-9-10-11-15-23-33(3,4)24-22-30(32)31-29(28-16-13-12-14-17-28)25-27-20-18-26(2)19-21-27/h12-14,16-21,29H,5-11,15,22-25H2,1-4H3,(H,31,32)

InChI key

NBYATBIMYLFITE-UHFFFAOYSA-N

Gene Information

human ... SOAT1(6646)
rat ... Soat1(81782)

Application

Sandoz 58-035 用于诱导小鼠腹腔巨噬细胞中未折叠蛋白反应（UPR）和模式识别受体（PRR）的同时激活。³

Biochem/physiol Actions

Sandoz 58-035 抑制胆固醇酯的积累，抑制培养物中动脉平滑肌细胞 95％的胆固醇酯化。¹它不影响肠道甘油三酯代谢。²

酰基辅酶 A：胆固醇酰基转移酶（ACAT）抑制剂。

Features and Benefits

该化合物由 Novartis 开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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Xanthohumol, a prominent prenyl flavonoid from the hop plant (Humulus lupulus L.), is suggested to be antiatherogenic since it reportedly increases high-density lipoprotein (HDL) cholesterol levels. It is not clear whether xanthohumol promotes reverse cholesterol transport (RCT), the most important

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Journal of clinical lipidology, 12(5), 1267-1279 (2018-08-06)

Cardiovascular risk is negatively correlated with cholesterol efflux capacity (CEC) from macrophages to high-density lipoproteins (HDLs) and positively correlated with fasting and nonfasting triglyceride-rich lipoproteins (TRLs). Pemafibrate, a novel selective peroxisome proliferator-activated receptor α modulator, robustly decreases the fasting TRL

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Journal of hepatology, 73(1), 113-120 (2020-02-18)

High-density lipoprotein cholesterol (HDL-C) levels are reduced in patients with chronic liver disease and inversely correlate with disease severity. During acute conditions such as sepsis, HDL-C levels decrease rapidly and HDL particles undergo profound changes in their composition and function.

Impact of Endothelial Lipase on Cholesterol Efflux Capacity of Serum and High-density Lipoprotein.

Irene Schilcher et al.

Scientific reports, 7(1), 12485-12485 (2017-10-04)

Endothelial lipase (EL) is a potent modulator of the structural and functional properties of HDL. Impact of EL on cholesterol efflux capacity (CEC) of serum and isolated HDL is not well understood and apparently contradictory data were published. Here, we

Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages.

Masato Furuhashi et al.

Scientific reports, 7(1), 217-217 (2017-03-18)

Cholesterol efflux capacity (CEC) from macrophages, the first step in the reverse cholesterol transport pathway, is inversely associated with residual risk for atherosclerotic cardiovascular disease. Fatty acid-binding protein 4 (FABP4) and FABP5 are expressed in both adipocytes and macrophages and

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Cholesterol Esterification

Cholesterol esterification enhances transport efficiency in lipoproteins for increased blood stream transport.

Discover Bioactive Small Molecules for Lipid Signaling Research

胆固醇酯化TEST

胆固醇酯化可改善运输。胆固醇酯可更轻松地封装在脂蛋白内部-增加了在血液中可轻松运输的胆固醇数量。

全球贸易项目编号

货号	GTIN
S9318-5MG	04061836961350
S9318-25MG	04061836961343

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