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S9446

Sphingosine Kinase 1 人

aqueous glycerol solution

别名:

SPHK 2

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关于此项目

UNSPSC Code:
12352204
NACRES:
NA.54
EC 号:
2.7.1.91 (BRENDA, IUBMB)
MDL number:
MFCD09265456
Specific activity:
≥10 units/μg
Recombinant:
expressed in baculovirus infected insect cells
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recombinant

expressed in baculovirus infected insect cells

Quality Segment

form

solution

specific activity

≥10 units/μg

mol wt

47 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... SPHK1(8877)

General description

Sphingosine 1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis.

Application

Sphingosine kinase 1 has been used in a study to assess the modulation of cellular S1P levels. Sphingosine kinase 1 has also been used in a study to investigate how FTY720 normalizes hyperglycemia.

Biochem/physiol Actions

Converts sphingosine to sphingosine-1-phosphate. SPHK1 shares two large conserved regions with SPHK2. While SPHK1 is found only in the cytosol, SPHK2 is localized in both the cytosol and nuclei.

Physical form

Supplied in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween 20, 50% glycerol, 3 mM DTT.
aqueous glycerol solution

Other Notes

One unit will produce 1.0 pmole of sphingosine-1-phosphate from ATP and D-erythro-sphingosine per minute at pH 7.4, 37 °C.

存储类别

10 - Combustible liquids

怎么回事？

WGK 1

闪点 (F)

Not applicable

闪点 (°C)

Not applicable

PPE（个人防护设备）

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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