S9564
分泌的淀粉样前体蛋白α 人
>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution
别名:
sAPPα
产品名称
分泌的淀粉样前体蛋白α 人, >90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution
recombinant
expressed in E. coli (N-terminal histidine tagged)
assay
>90% (SDS-PAGE)
form
buffered aqueous solution
mol wt
~100 kDa by SDS-PAGE
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... APP(351)
Application
人分泌型α淀粉样前体蛋白已用于酶联免疫吸附试验 (ELISA)。
Biochem/physiol Actions
淀粉样前体蛋白α是一种α分泌酶裂解的可溶性蛋白，具有神经保护特性。它来源于淀粉样前体蛋白。该蛋白质由612个氨基酸组成。几种 G 蛋白偶联受体可激活 αAPP 的分泌酶依赖性加工。它具有神经保护、神经源性和神经营养功能。淀粉样前体蛋白还可刺激基因表达和蛋白质表达。
General description
APP（淀粉样前体蛋白）基因定位于人染色体 21q21.3。它可编码一种整合膜蛋白。APPα是一种可溶性蛋白质，通过分泌酶γ的α连续裂解而产生。
Physical form
0.2 μm 过滤、溶于pH7.4 磷酸盐缓冲盐水的溶液
Preparation Note
在非变性条件下表达为可溶性蛋白并纯化。
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
C U Pietrzik et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(4), 1770-1775 (1998-03-21)
In various species, thyrotropin (TSH) is known to stimulate both differentiation and proliferation of thyroid follicle cells. This cell type has also been shown to express members of the Alzheimer amyloid precursor (APP) protein family and to release the secretory
Therapeutic Potential of Secreted Amyloid Precursor Protein APPsa
Frontiers in Molecular Neuroscience (2017)
Soluble ?-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth
Noriko Hasebe
PLoS ONE (2013)
S W Barger et al.
Brain research. Molecular brain research, 40(1), 116-126 (1996-08-01)
A significant fraction of the beta-amyloid precursor protein is proteolytically processed to yield large secreted forms (sAPP). These proteins have pleiotropic effects which potentially involve control of gene expression. We have investigated the influence of sAPP on the class of
Dementia: New Insights for the Healthcare Professional, 478-478 (2013)
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