S9564
分泌的淀粉样前体蛋白α 人
>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution
别名:
sAPPα
General description
APP（淀粉样前体蛋白）基因定位于人染色体 21q21.3。它可编码一种整合膜蛋白。APPα是一种可溶性蛋白质，通过分泌酶γ的α连续裂解而产生。
Application
人分泌型α淀粉样前体蛋白已用于酶联免疫吸附试验 (ELISA)。
Biochem/physiol Actions
淀粉样前体蛋白α是一种α分泌酶裂解的可溶性蛋白，具有神经保护特性。它来源于淀粉样前体蛋白。该蛋白质由612个氨基酸组成。几种 G 蛋白偶联受体可激活 αAPP 的分泌酶依赖性加工。它具有神经保护、神经源性和神经营养功能。淀粉样前体蛋白还可刺激基因表达和蛋白质表达。
Physical form
0.2 μm 过滤、溶于pH7.4 磷酸盐缓冲盐水的溶液
Preparation Note
在非变性条件下表达为可溶性蛋白并纯化。
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
In vivo BACE1 inhibition leads to brain A?
lowering and increased a-secretase processing of
APP without effect on Neuregulin-1
lowering and increased a-secretase processing of
APP without effect on Neuregulin-1
Sethu Sankaranarayanan
American Society for Engineering Education (2018)
Luo, J.J., et al.
Neuroscience Research, 63, 410-410 (2001)
S W Barger et al.
Journal of neurochemistry, 76(3), 846-854 (2001-02-07)
Microglial activation as part of a chronic inflammatory response is a prominent component of Alzheimer's disease. Secreted forms of the beta-amyloid precursor protein (sAPP) previously were found to activate microglia, elevating their neurotoxic potential. To explore neurotoxic mechanisms, we analyzed
Soluble ?-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth
Noriko Hasebe
PLoS ONE (2013)
C U Pietrzik et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(4), 1770-1775 (1998-03-21)
In various species, thyrotropin (TSH) is known to stimulate both differentiation and proliferation of thyroid follicle cells. This cell type has also been shown to express members of the Alzheimer amyloid precursor (APP) protein family and to release the secretory
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