S9576
SR8278
≥98% (HPLC)
别名:
1,2,3,4-四氢-2-[[[5-（甲硫基-2--2-噻吩基]羰基] -3-异喹啉羧酸乙酯
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关于此项目
经验公式（希尔记法）:
C18H19NO3S2
化学文摘社编号:
分子量:
361.48
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
SR8278, ≥98% (HPLC)
InChI key
UIEBLUZPSFAFOC-UHFFFAOYSA-N
SMILES string
CCOC(=O)C1Cc2ccccc2CN1C(=O)c3ccc(SC)s3
InChI
1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3
assay
≥98% (HPLC)
form
lyophilized powder
color
white
solubility
DMSO: ≥30 mg/mL
storage temp.
2-8°C
Quality Level
Application
SR8278可用作rev-erbα拮抗剂，研究胰高血糖素分泌对小鼠胰岛α细胞和β细胞的调节作用。
SR8278已被用作核受体亚家族1D组成员1（NR1D1）拮抗剂，以研究其对饥饿诱导的巨噬细胞的作用。
Biochem/physiol Actions
SR8278是核血红素受体REV-ERB拮抗剂。
SR8278是核血红素受体REV-ERB拮抗剂。REV-ERBα通过抑制靶基因活性在调节昼夜节律中起关键作用。另外，研究表明，REV-ERBα可调节脂质和葡萄糖代谢等代谢过程。 SR8278可阻断合成激动剂GSK4112增强REV-ERBα依赖性抑制的能力、刺激参与糖异生的REV-ERBα靶基因的表达。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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