Anti-SMOX (151-165) antibody produced in rabbit

Spermine oxidase (SMOX) gene mapped to human chromosome 20p13, is a flavin adenine dinucleotide (FAD)-dependent oxidase. It encodes nucleus and cytoplasmic specific splice variants.

synthetic peptide corresponding to amino acids 151-165 of human SMOX

Anti-SMOX (151-165) antibody produced in rabbit has been used in western blotting.

Spermine oxidase (SMOX) catabolizes spermine to spermidine, 3-aminopropanal and hydrogen peroxide. This catalytic activity of SMOX leads to apoptosis and DNA damage in gastric epithelial cells. It is highly expressed in H. pylori  infected gastritis tissues and in ulcerative colitis (UC). Induced SMOX expression in breast cancer using spermine analogs is regarded as an effective anticancer treatment regime. It is regarded as a key marker correlating chronic inflammation with epithelial carcinogenesis. Elevation in the SMO levels is observed in inflammatory bowel disease and is implicated in the immunopathogenesis of Citrobacter rodentium infection mediated colitis.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

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