生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~56 kDa
种属反应性
human
技术
western blot: 1:500-1:2,000
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SMOX(54498)
一般描述
Spermine oxidase (SMOX) gene mapped to human chromosome 20p13, is a flavin adenine dinucleotide (FAD)-dependent oxidase. It encodes nucleus and cytoplasmic specific splice variants.
免疫原
synthetic peptide corresponding to amino acids 151-165 of human SMOX
应用
Anti-SMOX (151-165) antibody produced in rabbit has been used in western blotting.
生化/生理作用
Spermine oxidase (SMOX) catabolizes spermine to spermidine, 3-aminopropanal and hydrogen peroxide. This catalytic activity of SMOX leads to apoptosis and DNA damage in gastric epithelial cells. It is highly expressed in H. pylori infected gastritis tissues and in ulcerative colitis (UC). Induced SMOX expression in breast cancer using spermine analogs is regarded as an effective anticancer treatment regime. It is regarded as a key marker correlating chronic inflammation with epithelial carcinogenesis. Elevation in the SMO levels is observed in inflammatory bowel disease and is implicated in the immunopathogenesis of Citrobacter rodentium infection mediated colitis.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Increased polyamines as protective disease modifiers in congenital muscular dystrophy
Kemaladewi DU, et al.
Human Molecular Genetics, 27(11), 1905-1912 (2018)
Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity
Hong SKS, et al.
Inflammatory bowel diseases, 16(9), 1557-1566 (2010)
Distinct immunomodulatory effects of spermine oxidase in colitis induced by epithelial injury or infection
Gobert AP, et al.
Frontiers in Immunology, 9, 1242-1242 (2018)
Freddy López-Contreras et al.
Frontiers in pharmacology, 10, 1670-1670 (2020-04-08)
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a
D U Kemaladewi et al.
Human molecular genetics, 27(11), 1905-1912 (2018-03-23)
Most Mendelian disorders, including neuromuscular disorders, display extensive clinical heterogeneity that cannot be solely explained by primary genetic mutations. This phenotypic variability is largely attributed to the presence of disease modifiers, which can exacerbate or lessen the severity and progression
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