SAB1300331
Anti-MLLT2 (N-term) antibody produced in rabbit
saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
别名:
Anti-2, Anti-ALL1 FUSED GENE FROM CHROMOSOME 4, Anti-MIXED LINEAGE LEUKEMIA, Anti-TRANSLOCATED TO
生物来源
rabbit
偶联物
unconjugated
抗体形式
saturated ammonium sulfate (SAS) precipitated
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
技术
indirect ELISA: 1:1000
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MLLT2(4299)
一般描述
MLLT2 is involved in acute leukemias through a chromosomal translocation t(4;11)(q21;q23) that involves mllt2 and mll/hrx. AF-4 (MLLT2), AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions. Stretches abundant in basic amino acids are also present in the three proteins. These results suggest that the different proteins fused to ALL-1 polypeptide(s) provide similar functional domains. AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus. The composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant negative mechanism in leukemogenesis.
免疫原
MLLT2 (NP_005926, 6-38)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MLLT2.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MLLT2.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
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