SAB1304901
ANTI-CCL22 (CENTER) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
C-C motif chemokine 22, CCL22, MDC, SCYA22
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
human
Application:
WB
Citations:
8
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
10625 Da
species reactivity
human
technique(s)
western blot: 1:250-1:500
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CCL22(6367)
General description
Macrophage-derived chemokine (MDC) is also known as C-C motif chemokine ligand 22 (CCL22). It is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated natural killer (NK) cells and cluster of differentiation 4 (CD4) T cells. The gene encoding it is localized on human chromosome 16. Recombinant human MDC is an 8.0kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Biochem/physiol Actions
Macrophage-derived chemokine (MDC) signals through the C-C chemokine receptor type 4 (CCR4). It chemo-attracts monocytes, dendritic cells and natural killer (NK) cells and aids in their function. The protein exerts human immunodeficiency virus (HIV) suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. It is expressed in various cancers and is involved in recruitment of regulatory T cells (Treg) within a tumor.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Satoshi Kimura et al.
Journal of atherosclerosis and thrombosis, 25(12), 1240-1254 (2018-05-26)
CCL22, mainly synthesized by monocyte-derived alternative (M2) macrophages, belongs to the CC family of chemokines and is involved in monocyte migration and recruitment. We have previously investigated CCL22 and histamine in atherosclerosis. Here, we investigated the hypothesis that CCL22 is
Dong Wang et al.
Cancer letters, 452, 244-253 (2019-04-01)
Immune dysfunction often occurs in malignant pleural effusion (MPE). In our previous study, TGF-β derived predominantly from macrophages plays an important role in impairing T cell cytotoxicity in MPE. Therefore, we aimed to investigate whether other immunoregulatory cells and factors
Hai-Xiang Gao et al.
Experimental lung research, 45(1-2), 1-12 (2019-04-30)
Objective: To study the role of miR-34c-5p targeting CCL22 in affecting the progression of chronic obstructive pulmonary disease (COPD). Methods: The dual-luciferase reporter gene assay was applied to verify the targeting relationship of miR-34c-5p and CCL22. The rats were randomly
Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of ? chemokines and RNases.
Cocchi F
Proceedings of the National Academy of Sciences of the USA, 109(14), 5411-5416 (2012)
Suppression of intratumoral CCL22 by type i interferon inhibits migration of regulatory T cells and blocks cancer progression.
Anz D
Cancer Research, 75(21), 4483-4493 (2015)
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