ANTI-USP51 (CENTER) antibody produced in rabbit

Ubiquitin specific peptidase 51 (USP51) encodes a deubiquitylating enzyme. USP51 is predominantly expressed in prostate, brain, lung, aorta and kidney. In human chromosome, the gene USP51 is localized on Xp11.

Ubiquitin specific peptidase 51 (USP51) in response to DNA damage deubiquitylates histone H2A at Lys13,15 (H2AK13,15ub) present at DNA double-strand breaks (DSBs) to maintain genome integrity. High expression of USP51 suppresses ionizing radiations induced damage on p53-binding protein 1(53BP1) and breast cancer type 1 susceptibility protein (BRCA1). Cells depleted with USP51 show an increase in G1 phase cells and decrease in S-phase cells and hence it is required for cell cycle progression. USP51 deubiquitinase zinc finger E-Box binding homeobox 1)(ZEB1) and stabilizes its expression, especially in breast tumour cells.

Supplied in PBS with 0.09% (W/V) sodium azide

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