SAB1305451
ANTI-USP51 (CENTER) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Deubiquitinating enzyme 51, USP51, Ubiquitin carboxyl-terminal hydrolase 51
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
79756 Da
种属反应性
human
技术
western blot: 1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... USP51(158880)
一般描述
Ubiquitin specific peptidase 51 (USP51) encodes a deubiquitylating enzyme. USP51 is predominantly expressed in prostate, brain, lung, aorta and kidney. In human chromosome, the gene USP51 is localized on Xp11.
生化/生理作用
Ubiquitin specific peptidase 51 (USP51) in response to DNA damage deubiquitylates histone H2A at Lys13,15 (H2AK13,15ub) present at DNA double-strand breaks (DSBs) to maintain genome integrity. High expression of USP51 suppresses ionizing radiations induced damage on p53-binding protein 1(53BP1) and breast cancer type 1 susceptibility protein (BRCA1). Cells depleted with USP51 show an increase in G1 phase cells and decrease in S-phase cells and hence it is required for cell cycle progression. USP51 deubiquitinase zinc finger E-Box binding homeobox 1)(ZEB1) and stabilizes its expression, especially in breast tumour cells.
外形
Supplied in PBS with 0.09% (W/V) sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
Zhen Zhang et al.
Signal transduction and targeted therapy, 5(1), 25-25 (2020-04-17)
Tumor metastasis is the most common cause of cancer-related deaths, yet it remains poorly understood. The transcription factor zinc-finger E-box binding homeobox 1 (ZEB1) is involved in the epithelial-to-mesenchymal transition (EMT) and plays a pivotal role in tumor metastasis. However
USP51 promotes deubiquitination and stabilization of ZEB1
Zhou Z, et al.
American Journal of Cancer Research, 7(10), 2020-2020 (2017)
Jianjun Li et al.
Cancer communications (London, England), 43(7), 765-787 (2023-06-30)
Programmed death ligand 1 (PD-L1) has been demonstrated to facilitate tumor progression and therapeutic resistance in an immune-independent manner. Nevertheless, the function and underlying signaling network(s) of cancer cell-intrinsic PD-L1 action remain largely unknown. Herein, we sought to better understand
Yongchang Gao et al.
International journal of biological sciences, 18(5), 2186-2201 (2022-03-29)
TNBC is characterized by high incidence of visceral metastasis and lacks effective clinical targets. This study aims to delineate the molecular mechanisms of SENP1 in TNBC invasion and metastasis. By using IHC to test the SENP1 expression in TNBC tissues
USP51 deubiquitylates H2AK13, 15ub and regulates DNA damage response
Wang Z, et al.
Genes & Development, 30(8), 946-959 (2016)
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