SAB1306582
抗-泛素 兔抗
IgG fraction of antiserum, buffered aqueous solution
别名:
UBC, 泛素, 聚泛素-C
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC, WB
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
77039 Da
species reactivity
human
technique(s)
immunofluorescence: 1:10-1:50, immunohistochemistry: 1:50-1:100, western blot: 1:1000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... UBC(7316)
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General description
泛素，也称为泛素C（UBC），是一种球状蛋白，由定位于人类染色体12q24.31的基因编码。编码的蛋白质由76个氨基酸组成。
Immunogen
一种在人泛素36-66个氨基酸之间的合成肽，在泛素样1结构域内
Application
兔抗泛素抗体可用于蛋白质印迹。
Biochem/physiol Actions
泛素在蛋白质降解中起主要作用。泛素介导的调节蛋白降解与各种过程的调节有关，例如细胞周期进程，信号转导，转录调节，受体下调和内吞作用。泛素介导的途径中的畸变有助于恶性转化。
Physical form
以含有0.09％（W/V）叠氮化钠的PBS形式提供
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3.
Board PG, et al.
Genomics, 12, 639-642 (1992)
The VHL short variant involves in protein quality control
Liu Y, et al.
Gene, 589, 63-71 (2016)
A Hershko et al.
Annual review of biochemistry, 67, 425-479 (1998-10-06)
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small protein. Ubiquitin-mediated degradation of regulatory proteins
Jia-Hua Qu et al.
eLife, 12 (2024-01-22)
Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) which included overexpression of a large number of proteins. Here, we conducted an unbiased phosphoproteomics analysis
Ubiquitin recognition by the proteasome
Saeki Y, et al.
Journal of Biochemistry, 161, 113-124 (2017)
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