SAB1306616
ANTI-PCM-1 (CENTER) antibody produced in rabbit
purified immunoglobulin, buffered aqueous solution
别名:
PCM1, Pericentriolar material 1 protein
产品名称
ANTI-PCM-1 (CENTER) antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
biological source
rabbit
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
228533 Da
species reactivity
human
technique(s)
flow cytometry: 1:10-1:50
immunofluorescence: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PCM1(5108)
Biochem/physiol Actions
Pericentriolar material 1 (PCM1) protein acts as a scaffold and facilitates the aggregation of target proteins to the centrosome during centrosome maturation. It forms a complex with Bardet-Biedl syndrome 4 protein (BBS4) and disrupted-in-schizophrenia 1 (DISC1) at the centrosome. PCM1 along with DISC1 and BBS4 plays a role in the centrosomal pathway that is associated with schizophrenia. It is involved in ciliogenesis by binding an E3 ligase enzyme to satellites. PCM1 regulates the primary cilia disassembly before mitotic entry by recruiting polo-like-kinase 1 (Plk1) to the pericentriolar matrix.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Pericentriolar material 1 (PCM1) is a centriolar satellite protein. The PCM1 gene is located on the human chromosome at 8p22.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Gang Wang et al.
Journal of cell science, 126(Pt 6), 1355-1365 (2013-01-25)
Primary cilia, which emanate from the cell surface, exhibit assembly and disassembly dynamics along the progression of the cell cycle. However, the mechanism that links ciliary dynamics and cell cycle regulation remains elusive. In the present study, we report that
Atsushi Kamiya et al.
Archives of general psychiatry, 65(9), 996-1006 (2008-09-03)
A role for the centrosome has been suggested in the pathology of major mental illnesses, especially schizophrenia (SZ). To show that pericentriolar material 1 protein (PCM1) forms a complex at the centrosome with disrupted-in-schizophrenia 1 (DISC1) and Bardet-Biedl syndrome 4
Lei Wang et al.
eLife, 5 (2016-05-06)
To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding the PCM1 protein, an integral component of satellites. PCM1 null human cells show marked defects in ciliogenesis, precipitated by the loss of specific proteins from satellites
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