biological source
(Mouse)
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
form
liquid
mol wt
31475Da
species reactivity
mouse
technique(s)
dot blot: 1:500
isotype
IgG
NCBI accession no.
storage temp.
-10 to -25°C
target post-translational modification
phosphorylation (pSer12)
Gene Information
mouse ... Casp3(12367)
General description
This gene encodes a protein which is a member of thecysteine-aspartic acid protease (caspase) family. Sequentialactivation of caspases plays a central role in the execution-phaseof cell apoptosis. Caspases exist as inactive proenzymes whichundergo proteolytic processing at conserved aspartic residues toproduce two subunits, large and small, that dimerize to form theactive enzyme. This protein cleaves and activates caspases 6, 7 and9, and the protein itself is processed by caspases 8, 9 and 10. Itis the predominant caspase involved in the cleavage of amyloid-beta4A precursor protein, which is associated with neuronal death inAlzheimer′s disease. Alternative splicing of this gene results intwo transcript variants that encode the same protein. [provided byRefSeq].
Biochem/physiol Actions
This mouse CASP3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S12 of mouse CASP3.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable