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SAB1309022

Anti-phospho-mouse TSC1(S561) antibody produced in rabbit

Name: Anti-phospho-mouse TSC1(S561) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

别名:

Hamartin, Tuberous sclerosis 1 protein homolog, Tsc1, Kiaa0243

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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属性

biological source

(Mouse)

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

mol wt

128746Da

species reactivity

mouse

technique(s)

dot blot: 1:500

isotype

IgG

NCBI accession no.

NP_075025.2

storage temp.

-10 to -25°C

target post-translational modification

phosphorylation (pSer561)

Gene Information

mouse ... Tsc1(64930)

说明

General description

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Biochem/physiol Actions

This mouse TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S561 of mouse TSC1.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c