biological source
(Human)
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
form
liquid
mol wt
280739Da
species reactivity
mouse, human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50~100, western blot: 1:1000, western blot: 1:500-1:2000
isotype
IgG
storage temp.
-10 to -25°C
Gene Information
human ... PSEN1(5663)
General description
Alzheimer′s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.
Biochem/physiol Actions
This Presenilin 1 (PSEN1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-359 amino acids from the C-terminal region of human Presenilin 1 (PSEN1).
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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