Anti-CYC1 antibody produced in rabbit

Cytochrome c1 (CYC1) is a heme-containing constituent of mitochondrial complex III.[1] It is encoded by the gene mapped to human chromosome 8q24.3.[2] The encoded protein is attached to the phospholipid bilayer by a single C-proximal transmembrane segment.[3]

CYC1 (NP_001907.2, 1 a.a. ~ 325 a.a) full-length human protein.

Sequence
MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVMLSALGMLAAGGAGLAVALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK

Cytochrome c1 (CYC1) stimulates oxidative phosphorylation activity in human ductal carcinoma in- situ (DCIS) and thus, plays an essential role in cell proliferation and comedo necrosis.[4] CYC1 expression is implicated in breast cancer progression and might act as a predictive factor for poor prognosis in breast cancer patients. Variation in the gene expression leads to mitochondrial complex III deficiency.[1]

Solution in phosphate buffered saline, pH 7.4

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