产品名称
抗-SLC40A1 兔抗, purified immunoglobulin, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLC40A1(30061)
Biochem/physiol Actions
铁转运蛋白-1（FPN1）是一种铁输出蛋白，参与铁从外部和内部位点转移到血液中的过程，从而维持铁稳态。FPN1主要从巨噬细胞和肠细胞输出铁，也会从肝细胞输出铁。FPN1也能将铁从胎盘转运到胎儿体内。FPN1在翻译后受铁调素调节，最终降解。该基因突变会导致铁在巨噬细胞和肠道中积累和亚临床贫血，从而导致铁转运蛋白疾病。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
该基因所编码的蛋白是一种可能参与了来自十二指肠上皮细胞铁输出的细胞膜蛋白。该基因的缺陷是4型血色素沉着病（HFE4）的一个诱因。（由RefSeq提供）
Immunogen
SLC40A1 (NP_055400.1, 1 a.a. ~ 571 a.a) 人全长蛋白。
序列
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV
序列
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV
Physical form
溶于pH7.4的磷酸盐缓冲盐水中的溶液
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2.
Yanatori I
The Journal of Biological Chemistry, 291(33), 17303-17318 (2016)
Human macrophage ferroportin biology and the basis for the ferroportin disease.
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Hepatology, 65(5), 1512-1525 (2017)
miR-20a regulates expression of the iron exporter ferroportin in lung cancer.
Babu KR and Muckenthaler MU
Journal of Molecular Medicine, 94(3), 347-359 (2016)
Ironing out Ferroportin.
Drakesmith H
Cell Metabolism, 22(5), 777-787 (2015)
Huiying Liu et al.
Journal of neurochemistry, 152(3), 397-415 (2019-08-24)
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