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SAB1402157

Monoclonal Anti-CRY2 antibody produced in mouse

Name: Monoclonal Anti-CRY2 antibody produced in mouse
Brand: SIGMA

clone 3H4, purified immunoglobulin, buffered aqueous solution

别名:

FLJ10332, HCRY2, KIAA0658, PHLL2

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关于此项目

NACRES:

NA.43

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

3H4, monoclonal

Application:

ELISA (c), ELISA (i), IF, WB

Citations:

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属性

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3H4, monoclonal

form

buffered aqueous solution

mol wt

antigen ~36.12 kDa

species reactivity

human

technique(s)

capture ELISA: suitable, immunofluorescence: suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL

isotype

IgG2aκ

NCBI accession no.

NM_021117

UniProt accession no.

Q49AN0

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CRY2(1408)

说明

General description

Cryptochrome circadian regulator 2 (CRY2) is a core circadian gene and transcriptional repressor. CRY2 gene is located on the human chromosome 11p11.2.

Immunogen

CRY2 (NP_066940.1, 141 a.a. ~ 231 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
VEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGFPTEGLGPAVWQG

Biochem/physiol Actions

Cryptochrome circadian regulator 2 (CRY2) is involved in DNA damage checkpoint control and cell cycle progression. It maintains the circadian rhythm through a circadian feedback loop. It is also important in immune system coordination and hematologic system development. CRY2 is a potential circadian biomarker for non-Hodgkin′s lymphoma (NHL). CRY2 is linked to rapid cycling in bipolar disorder. CRY2 functions as light-sensitive magnetosensor.

Physical form

Solution in phosphate buffered saline, pH 7.4

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

08197-3H4

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Clock-Cancer Connection in Non-Hodgkin's Lymphoma: A Genetic Association Study and Pathway Analysis of the Circadian Gene Cryptochrome 2

Hoffman AE, et al.

Cancer Research, 69(8), 3605-3613 (2009)

CRY2 is associated with rapid cycling in bipolar disorder patients

Sjoholm LK, et al.

Testing, 5(9), e12632-e12632 (2010)

Variants in circadian genes and prostate cancer risk: a population-based study in China

Chu Lw, et al.

Prostate Cancer and Prostatic Diseases, 11(4), 342-342 (2008)

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全球贸易项目编号

货号	GTIN
SAB1402157-100UG	04061829607869