SAB1402390
单克隆抗-VEGF 小鼠抗
clone 3F7, purified immunoglobulin, buffered aqueous solution
别名:
MGC70609, VEGF, VEGF-A, VPF
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关于此项目
Conjugate:
unconjugated
Clone:
3F7, monoclonal
Application:
ELISA (c), ELISA (i), PLA, WB
Citations:
14
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3F7, monoclonal
form
buffered aqueous solution
mol wt
antigen ~37.55 kDa
species reactivity
human
technique(s)
capture ELISA: suitable, indirect ELISA: suitable, proximity ligation assay: suitable, western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... VEGFA(7422)
General description
血管内皮生长因子（VEGF）基因位于人类染色体6p21.3上，被认为编码四种不同的同工酶。它通过三种受体发出信号；Fms样酪氨酸激酶（flt-1），KDR基因产物（KDR的鼠同源物是flk-1基因产物）和flt4基因产物。该蛋白质在血管化组织中表达。
该基因是 PDGF/VEGF 生长因子家族的成员，编码的蛋白质通常以二硫键连接的同源二聚体形式存在。该蛋白是一种糖基化的丝裂原，专门作用于内皮细胞，具有多种作用，包括介导血管通透性增加、诱导血管生成、血管生成和内皮细胞生长、促进细胞迁移和抑制细胞凋亡。这种蛋白质水平升高与 POEMS 综合征有关，也称为 Crow-Fukase 综合征。该基因的突变与增殖性和非增殖性糖尿病视网膜病变有关。可编码自由分泌或细胞相关亚型的选择性剪接转录变体已被表征。也有证据表明在第一个 AUG 的上游使用非 AUG (CUG) 翻译起始位点，并与第一个 AUG 同框，可导致额外的同种型。（RefSeq 提供）
Immunogen
带有 GST 标签的 VEGF (NP_003367，27 a.a.~130 a.a) 部分重组蛋白。仅 GST 标签的分子量为 26 kDa。
序列
APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCEC
序列
APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCEC
Application
小鼠抗 VEGF 单克隆抗体可用于免疫印迹实验。
Biochem/physiol Actions
血管内皮生长因子（VEGF）是一种强效生长和血管生成细胞因子。它可刺激内皮细胞的增殖和存活。它可促进血管生成和血管通透性。VEGF参与诱导肿瘤转移和眼内新血管综合征，其编码基因的多态性与2型糖尿病的糖尿病性视网膜病变有关。
Physical form
溶于磷酸盐缓冲盐水，pH 7.4
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Libin Ma et al.
International journal of molecular medicine, 46(1), 265-279 (2020-07-07)
The aim of the present study was to explore the mechanism by which Notch1‑small activating (sa)RNA restored androgen sensitivity in human metastatic castration‑resistant prostate cancer (CRPC). After transfection of Notch1‑saRNA‑1480 in PC3 cells, the expression of Notch1 and androgen receptor (AR) was
Vegf, vegf-B, vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa
Thierry Andree
Cancer Cell (2000)
Yue Zhao et al.
Scientific reports, 6, 28627-28627 (2016-06-25)
The interaction between endothelial cells (ECs) and smooth muscle cells (SMCs) plays a critical role in the maintenance of vessel wall homeostasis. The X-box binding protein 1 (XBP1) plays an important role in EC and SMC cellular functions. However, whether
Preliminary study on decreasing the expression of FOXP3 with miR-155 to inhibit diffuse large B-cell lymphoma
Jincheng Z
Oncology Letters (2017)
A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes
Awata T
Diabetes (2002)
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