Monoclonal Anti-MYLIP antibody produced in mouse

Mouse monoclonal antibody raised against a full-length recombinant MYLIP.

Myosin regulatory light chain interacting protein (MYLIP) is an E3 ubiquitin ligase. The gene encoding it is localized on human chromosome 6p22.3.

MYLIP (AAH02860, 1 a.a. ~ 445 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI

Myosin regulatory light chain interacting protein (MYLIP) might have a role in cholesterol uptake. It modulates the levels of low density lipoprotein receptor by controlling the ubiquitination of the intracellular tail of the receptor and its lysosomal degradation. Overexpression of the protein in mice livers has been shown to cause hypercholesterolemia and atherosclerosis.

Solution in phosphate buffered saline, pH 7.4

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