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SAB1404654

Monoclonal Anti-RAB7L1 antibody produced in mouse

Name: Monoclonal Anti-RAB7L1 antibody produced in mouse
Brand: SIGMA

clone 1B10, purified immunoglobulin, buffered aqueous solution

别名:

DKFZp686P1051, RAB7L

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

1B10, monoclonal

Application:

ELISA (c), ELISA (i), WB

Citations:

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属性

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1B10, monoclonal

form

buffered aqueous solution

mol wt

antigen ~48.44 kDa

species reactivity

human

technique(s)

capture ELISA: suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL

isotype

IgG2bκ

NCBI accession no.

BC002585

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RAB7L1(8934)

说明

General description

RAB7L1 (Rab-7-like protein 1, also referred to as RAB29) is a cytosolic GTPase. The gene encoding it is localized on human chromosome 1q32. Mouse monoclonal antibody raised against a full-length recombinant RAB7L1.

Immunogen

RAB7L1 (AAH02585, 1 a.a. ~ 203 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDYEIVRLQLWDIAGQERFTSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPNGEPVPCLLLANKCDLSPWAVSRDQIDRFSKENGFTGWTETSVKENKNINEAMRVLIEKMMRNSTEDIMSLSTQGDYINLQTKSSSWSCC

Biochem/physiol Actions

RAB7L1 (Rab-7-like protein 1, also referred to as RAB29) modulates protein transport from the Golgi apparatus to lysosomes. It also modulates phagocytosis. RAB7L1 has been associated with Parkinson′s disease.

Physical form

Solution in phosphate buffered saline, pH 7.4

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

09219-1B10

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An association analysis of the rs1572931 polymorphism of the RAB7L1 gene in Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy in China.

X-Y Guo et al.

European journal of neurology, 21(10), 1337-1343 (2014-07-22)

Recently, the rs1572931 single-nucleotide polymorphism (SNP) of the putative promoter of the member RAS oncogene family-like 1 (RAB7L1) gene was reported to be associated with reduced risk for Parkinson's disease (PD) in the Ashkenazi Jewish population. Ethnic-specific effects are an

A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor.

Shicong Wang et al.

PloS one, 9(5), e96242-e96242 (2014-05-03)

Rab29 (also referred as Rab7L1) is a novel Rab protein, and is recently demonstrated to regulate phagocytosis and traffic from the Golgi to the lysosome. However, its roles in membrane trafficking have not been investigated extensively. Our results in this

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.

David A MacLeod et al.

Neuron, 77(3), 425-439 (2013-02-12)

Recent genome-wide association studies have linked common variants in the human genome to Parkinson's disease (PD) risk. Here we show that the consequences of variants at 2 such loci, PARK16 and LRRK2, are highly interrelated, both in terms of their

全球贸易项目编号

货号	GTIN
SAB1404654-100UG	04061829627850