SAB1408000
Anti-GRHL2 antibody produced in mouse
purified immunoglobulin, buffered aqueous solution
别名:
BOM, DFNA28, FLJ11172, FLJ13782, MGC149294, MGC149295, TFCP2L3
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
indirect immunofluorescence
western blot
western blot
Species reactivity:
human
Citations:
6
Technique(s):
indirect immunofluorescence: suitable
western blot: 1 μg/mL
western blot: 1 μg/mL
Uniprot accession no.:
产品名称
Anti-GRHL2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~71.1 kDa
species reactivity
human
technique(s)
indirect immunofluorescence: suitable
western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GRHL2(79977)
Application
Anti-GRHL2 antibody produced in mouse has been used in:
- Immunofluorescence
- Western blotting
- Co-immunoprecipitation
- Immunohistochemistry
Biochem/physiol Actions
Grainyhead like transcription factor 2 (GRHL2) inhibits epithelial-to-mesenchymal transition, which is necessary for cell migration. It is involved in neural tube closure, epithelial morphogenesis and barrier formation during embryogenesis. It contributes to carcinogenesis. GRHL2 regulates epithelial plasticity of pancreatic ductal adenocarcinoma (PDAC) progression.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Grainyhead like transcription factor 2 (GRHL2) encodes a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28). Grainyhead like transcription factor 2 (GRHL2) is an epithelial regulatory factor. GRHL2 is homologous to Drosophila grainyhead. GRHL2 gene is located on human chromosome 8q22.3.
Immunogen
GRHL2 (NP_079191.1, 1 a.a. ~ 625 a.a) full-length human protein.
Sequence
MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYDQTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLVKRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKVTLMEI
Sequence
MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYDQTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLVKRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKVTLMEI
Physical form
Solution in phosphate buffered saline, pH 7.4
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Grhl2 regulation of SPINT1 expression controls salivary gland development
Matsushita T, et al.
Biochemical and Biophysical Research Communications, 137(22) (2018)
The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex
Werth M, et al.
Development, 137(22), 3835-3845 (2010)
Bridging cancer biology with the clinic: relative expression of a GRHL2-mediated gene-set pair predicts breast cancer metastasis
Yang X, et al.
PLoS ONE, 8(2), e56195-e56195 (2013)
Grainyhead-like 2 (GRHL 2) regulates epithelial plasticity in pancreatic cancer progression
Nishino H, et al.
Cancer Medicine, 6(11) (2017)
Novel androgen receptor co-regulator GRHL2 exerts both oncogenic and anti-metastatic functions in prostate cancer
Paltoglou S, et al.
Cancer Research, 137(22) (2017)
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