SAB1408259
Anti-MRGPRX2 antibody produced in mouse
purified immunoglobulin, buffered aqueous solution
别名:
MRGX2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
FACS, WB
Citations:
4
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~37.1 kDa
species reactivity
human
technique(s)
flow cytometry: suitable, western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MRGPRX2(117194)
General description
Mas-related G protein-coupled receptor X2 (MRGPRX2) belonging to the class A GPCR/Mas-related gene family is expressed in sensory neurons, mast cells, and keratinocytes. It has seven transmembrane (TM) α-helices. MRGPRX2 mRNA is found at a high level in the skin. It is also detected in adipose tissue, esophagus, urinary bladder, and lungs. MRGPRX2 gene with two-exon is mapped on human chromosome 11p15.
Immunogen
MRGPRX2 (NP_473371.1, 1 a.a. ~ 330 a.a) full-length human protein.
Sequence
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
Sequence
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
Biochem/physiol Actions
Mas-related G protein-coupled receptor X2 (MRGPRX2) expressed on mast cells acts as an important receptor for pseudo-allergic responses induced by drugs. It is involved in the evolution of the human nervous system. It is also crucial to mast cells. MRGPRX2 gene mutation impairs the risk of anaphylactic actions facilitated by the MRGPRX2 receptor.
Physical form
Solution in phosphate buffered saline, pH 7.4
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Chalatip Chompunud Na Ayudhya et al.
International journal of molecular sciences, 22(10) (2021-06-03)
The neuropeptide substance P (SP) mediates neurogenic inflammation and pain and contributes to atopic dermatitis in mice through the activation of mast cells (MCs) via Mas-related G protein-coupled receptor (GPCR)-B2 (MrgprB2, human ortholog MRGPRX2). In addition to G proteins, certain
Haihui Wu et al.
Progress in histochemistry and cytochemistry, 50(1-2), 11-17 (2015-06-25)
Mas-related genes (Mrgs) belong to a large family of G protein-coupled receptor genes found in rodents. Human MRGX proteins are G protein-coupled 7-transmembrane proteins sharing 41-52% amino acid identity with each other, but have no orthologs in rodents. MrgX2 is
Grzegorz Porebski et al.
Frontiers in immunology, 9, 3027-3027 (2019-01-09)
The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic secretagogues and neurokinins. A number of commonly used small-molecule drugs (e.g., neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to activate these receptors under in vitro
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB1408259-50UG | 04061835696963 |