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SAB1409854

Monoclonal Anti-CAMK2D antibody produced in mouse

Name: Monoclonal Anti-CAMK2D antibody produced in mouse
Brand: SIGMA

clone 1B11, purified immunoglobulin, buffered aqueous solution

别名:

CAMKD, DKFZp686G23119, DKFZp686I2288, MGC44911

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

1B11, monoclonal

Application:

ELISA (i), WB

Citations:

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属性

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1B11, monoclonal

form

buffered aqueous solution

mol wt

antigen 37.73 kDa

species reactivity

human

technique(s)

indirect ELISA: suitable, western blot: 1-5 μg/mL

isotype

IgG2aκ

NCBI accession no.

BC032784

UniProt accession no.

Q13557

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CAMK2D(817)

说明

Immunogen

CAMK2D (AAH32784, 301 a.a. ~ 410 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
KGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPI

Biochem/physiol Actions

As a subunit of the calcium/calmodulin dependent protein kinase II complex, calcium/calmodulin dependent protein kinase II complex δ (CAMK2D) modulates the functions of ion channels and Ca²⁺ handling proteins. It also regulates the phosphorylation and acetylation of histones. It has been shown to be overexpressed in the myocardium of diabetic patients.

Physical form

Solution in phosphate buffered saline, pH 7.4

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存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

07184-1B11

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Control of histone H3 phosphorylation by CaMKIIδ in response to haemodynamic cardiac stress.

Salma Awad et al.

The Journal of pathology, 235(4), 606-618 (2014-11-26)

Heart failure is associated with the reactivation of a fetal cardiac gene programme that has become a hallmark of cardiac hypertrophy and maladaptive ventricular remodelling, yet the mechanisms that regulate this transcriptional reprogramming are not fully understood. Using mice with

The role of CaMKII in diabetic heart dysfunction.

Lorna Daniels et al.

Heart failure reviews, 20(5), 589-600 (2015-07-23)

Diabetes mellitus (DM) is an increasing epidemic that places a significant burden on health services worldwide. The incidence of heart failure (HF) is significantly higher in diabetic patients compared to non-diabetic patients. One underlying mechanism proposed for the link between

Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium.

Samuel Sossalla et al.

Circulation research, 107(9), 1150-1161 (2010-09-04)

Heart failure (HF) is known to be associated with increased Ca(2+)/calmodulin-dependent protein kinase (CaMK)II expression and activity. There is still controversial discussion about the functional role of CaMKII in HF. Moreover, CaMKII inhibition has never been investigated in human myocardium.

全球贸易项目编号

货号	GTIN
SAB1409854-100UG	04061829661649