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Merck
CN

SAB1410813

Anti-MYOD1 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

别名:

MYF3, MYOD, PUM, bHLHc1

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NACRES:
NA.41
UNSPSC Code:
12352203

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产品名称

Anti-MYOD1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 34.5 kDa

species reactivity

mouse, human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_002478.4

UniProt accession no.

P15172

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MYOD1(4654)

Biochem/physiol Actions

Myogenic differentiation 1 (MYOD1) associates with histone-modifying enzymes and stimulates muscle differentiation by elevating the expression of histone H3 mono methyl K4 (H3K4me1) and histone H3 acetyl 27 (H3K27ac). MyoD1 staining can be considered as a key adjunct in the sorting of pediatric soft-tissue sarcomas. Mutation in the gene is associated with the pathogenesis of perinatally lethal fetal akinesia.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Myogenic differentiation 1 (MYOD1) is encoded by the gene mapped to human chromosome 11p15.1. The encoded protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. MYOD1 is expressed exclusively during normal skeletal muscle myogenesis and in rhabdomyosarcomas.

Immunogen

MYOD1 (NP_002469.2, 1 a.a. ~ 320 a.a) full-length human protein.

Sequence
MELLSPPLRDVDLTAPDGSLCSFATTDDFYDDPCFDSPDLRFFEDLDPRLMHVGALLKPEEHSHFPAAVHPAPGAREDEHVRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQDAAPPGAAAAFYAPGPLPPGRGGEHYSGDSDASSPRSNCSDGMMDYSGPPSGARRRNCYEGAYYNEAPSEPRPGKSAAVSSLDCLSSIVERISTESPAAPALLLADVPSESPPRRQEAAAPSEGESSGDPTQSPDAAPQCPAGANPNPIYQVL

Physical form

Solution in phosphate buffered saline, pH 7.4

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存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
09061

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Deficiency of the myogenic factor MyoD causes a perinatally lethal fetal akinesia.
Watson CM
Journal of medical Genetics, 53, 264-269 (2016)
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
Kohsaka S
Nature Genetics, 46, 595-600 (2014)
Myogenic regulatory protein (MyoD1) expression in childhood solid tumors: diagnostic utility in rhabdomyosarcoma.
Dias P
The American Journal of Pathology, 137, 1283-1291 (1990)

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