SAB1412447
ANTI-HOXB7 antibody produced in mouse
clone 4C6, purified immunoglobulin, buffered aqueous solution
别名:
HHO.C1, HOX2, HOX2C, HOXB7, Hox-2.3
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
4C6, monoclonal
Application:
immunohistochemistry
indirect ELISA
western blot
indirect ELISA
western blot
Species reactivity:
human
Citations:
8
Technique(s):
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
indirect ELISA: suitable
western blot: 1-5 μg/mL
Uniprot accession no.:
产品名称
ANTI-HOXB7 antibody produced in mouse, clone 4C6, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
4C6, monoclonal
form
buffered aqueous solution
mol wt
antigen 33 kDa
species reactivity
human
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HOXB7(3217)
Biochem/physiol Actions
Homeobox B7 (HOXB7) has a role in many cellular processes. It has been shown to be expressed in hepatocellular carcinoma. HOXB7 may also have a role in cell migration and invasion in gastric cancer. This transcription factor is vital for tissue differentiation and embryogenesis. HOXB7 may be a potential drug target in various cancers. The protein has the capacity to induce the expression of genes associated with tumor invasion and angiogenesis.
General description
Homeobox B7 (HOXB7) is part of the HOX gene family and is expressed in embryonic tissues. The gene encoding it is localized on human chromosome 17q21.32.
Immunogen
HOXB7 (NP_004493, 55 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MQGLYPGGGGMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDSAKAAGAKEQRDSDLAA
Sequence
MQGLYPGGGGMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDSAKAAGAKEQRDSDLAA
Physical form
Solution in phosphate buffered saline, pH 7.4
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Identification of several potential chromatin binding sites of HOXB7 and its downstream target genes in breast cancer.
Heinonen H
International Journal of Cancer. Journal International Du Cancer, 137, 2374-2383 (2015)
The roles of HOXB7 in promoting migration, invasion, and anti-apoptosis in gastric cancer.
Joo MK, et.al.
Journal of Gastroenterology and Hepatology, 31, 1717-1726 (2016)
HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells.
Ma R
Molecular Medicine Reports, 12, 4901-4908 (2015)
HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis.
Chile T
BMC Cancer (2013)
Serologic analysis of ovarian tumor antigens reveals a bias toward antigens encoded on 17q.
Stone B
International Journal of Cancer. Journal International Du Cancer, 104, 73-84 (2003)
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