SAB2100200
抗-BACE1 兔抗
affinity isolated antibody
别名:
抗-β-位点APP-切割酶1, 抗-ASP2, 抗-BACE, 抗-FLJ90568, 抗-HSPC104
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
rabbit, bovine, guinea pig, mouse, rat, horse, dog, human
Citations:
6
Technique(s):
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-BACE1 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
51 kDa
species reactivity
rabbit, bovine, guinea pig, mouse, rat, horse, dog, human
concentration
0.5 mg - 1 mg/mL
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BACE1(23621)
Other Notes
合成肽位于以下区域内： GQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTY
Physical form
本品为溶于1x PBS缓冲液的纯化抗体，含0.09% (w/v) 叠氮化钠和2%蔗糖。
Biochem/physiol Actions
β位点APP裂解酶（BACE-1）作为淀粉样蛋白-β-肽（Aβ）的限速酶。BACE-1的过表达导致β-分泌酶活性增加。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
β-位点APP裂解酶（BACE-1）被称为β-分泌酶。它由N端信号肽（SP）、前肽（Pro）结构域、催化结构域、跨膜结构域和C端尾部组成。
BACE1是肽酶A1蛋白家族的成员，是主要在高尔基体中发现的I型整合膜糖蛋白和天冬氨酸蛋白酶。
Immunogen
靶向人BACE1的N端区域的合成肽
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo
Zhao L, et al.
Cells, 8(5), 474-474 (2019)
Proteolytic processing of Neuregulin-1
Willem M
Brain Research Bulletin, 126(5), 178-182 (2016)
beta-Site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways
Tamagno E, et al.
Journal of Neurochemistry, 92(3), 628-636 (2005)
Edward T Parkin et al.
PloS one, 17(1), e0255715-e0255715 (2022-01-14)
The amyloid cascade hypothesis proposes that excessive accumulation of amyloid beta-peptides is the initiating event in Alzheimer's disease. These neurotoxic peptides are generated from the amyloid precursor protein via sequential cleavage by β- and γ-secretases in the 'amyloidogenic' proteolytic pathway.
Chang Qu et al.
Journal of advanced research, 35, 231-243 (2022-01-14)
Honokiol (HO) exerts neuroprotective effects in several animal models of Alzheimer's disease (AD), but the poor dissolution hampers its bioavailability and therapeutic efficacy. A novel honokiol nanoscale drug delivery system (Nano-HO) with smaller size and excellent stability was developed in
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