SAB2101415
Anti-MAFB antibody produced in rabbit
affinity isolated antibody
别名:
Anti-KRML, Anti-MGC43127, Anti-V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
登录 查看组织和合同定价。
选择尺寸
关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
human, rat, guinea pig, horse, bovine, mouse, dog
Citations:
6
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
Anti-MAFB antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
36 kDa
species reactivity
human, rat, guinea pig, horse, bovine, mouse, dog
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MAFB(9935)
Biochem/physiol Actions
MAF bZIP transcription factor B (MAFB) has been implicated in the development of the hindbrain structures, thymus, interneurons, pancreatic islet cells and the hematopoietic system. In mouse, it helps in lip and palate development. MAFB regulates lineage-specific gene expression by suppressing the Ets-1-mediated transcription. The encoded protein plays an essential role in islet α-cell function. In addition, MAFB also regulates genes involved in both endocrine α- and β-cell differentiation. The protein acts as a modulator and marker of adipose tissue inflammation. Mutations in the gene is associated with the development of multicentric carpo-tarsal osteolysis (MCTO).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
MAF bZIP transcription factor B (MAFB) is encoded by the gene mapped to human chromosome 20q12. The encoded protein is a member of the maf oncogene family and is ubiquitously expressed in variety of tissues. MAFB is a 311 amino acid protein characterized with a typical basic leucine zipper (bZIP) domain in its C-terminal region.
Immunogen
Synthetic peptide directed towards the N terminal region of human MAFB
Other Notes
Synthetic peptide located within the following region: APQGSATAAEPQPGDPARASQDSADPQAPAQGNFRGSWDCSSPEGNGSPE
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.
Artner I
Diabetes, 55, 297-304 (2006)
MAFB as a novel regulator of human adipose tissue inflammation.
Pettersson AM
Diabetologia, 58, 2115-2123 (2015)
The identification of MAFB mutations in eight patients with multicentric carpo-tarsal osteolysis supports genetic homogeneity but clinical variability.
Mehawej C
American Journal of Medical Genetics. Part A, 161A, 3023-3029 (2013)
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
Beaty TH
Nature Genetics, 42, 525-529 (2010)
MafB Is an Interaction Partner and Repressor of Ets-1 That Inhibits Erythroid Differentiation
Sieweke MH
Cell, 85, 49-60 (1996)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持