SAB2102971
Anti-ZRANB2 (ab1) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-DKFZp686J1831, Anti-DKFZp686N09117, Anti-FLJ41119, Anti-ZIS, Anti-Zinc finger, RAN-binding domain containing 2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
human, horse, rat, bovine, mouse, guinea pig, rabbit, dog
Citations:
4
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
Anti-ZRANB2 (ab1) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
37 kDa
species reactivity
human, horse, rat, bovine, mouse, guinea pig, rabbit, dog
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ZRANB2(9406)
Biochem/physiol Actions
ZRANB2 is a splice factor required for alternative splicing of SFRS10/TRA2B transcripts. It may interfere with constitutive 5′-splice site selection. Zinc finger Ran-binding domain containing protein 2 (ZRANB2) promotes differential splicing of numerous primary transcripts. Alternative splicing of transcripts might be associated with cancer. ZRANB2 is upregulated in grade III ovarian serous papillary carcinoma. The C-terminal interacts with spliceosomal proteins and the N- terminal helps in RNA recognition.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Zinc finger ran-binding domain containing protein 2 (ZRANB2) is a part of supraspliceosome. It is present in the nucleus of human cells. This protein contains a C-terminal arginine/serine rich domain and two N-terminal RanBP2-type zinc fingers. ZRANB2 gene is located on human chromosome 1p31.1.
Immunogen
Synthetic peptide directed towards the N terminal region of human ZRANB2
Other Notes
Synthetic peptide located within the following region: KTCSNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENVEYIEREESD
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
ZRANB2: Structural and functional insights into a novel splicing protein
Mangs A, et al.
The International Journal of Biochemistry & Cell Biology, 40(11) (2008)
Crystallization of a ZRANB2--RNA complex
Loughlin F, et al.
Acta Crystallographica Section F, Structural Biology and Crystallization Communications, 64(12) (2008)
Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder
Moreau M, et al.
Biological Psychiatry, 69(2) (2011)
Yee Hwa J Yang et al.
Molecular biology reports, 40(9), 5381-5395 (2013-05-15)
Alternative splicing is a major source of protein diversity in humans. The human splicing factor zinc finger, Ran-binding domain containing protein 2 (ZRANB2) is a splicing protein whose specific endogenous targets are unknown. Its upregulation in grade III ovarian serous
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