biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
54 kDa
species reactivity
human
concentration
0.5-1 mg/mL
technique(s)
immunoblotting: suitable
accession no.
NM_152649
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MLKL(197259)
General description
混合谱系激酶结构域样蛋白(MLKL)由位于人类染色体16q23的基因编码。活化的MLKL定位于细胞膜上。
Immunogen
指向人 MLKL N 端区域的合成肽
Biochem/physiol Actions
混合谱系激酶结构域样蛋白(MLKL)主要引起受体相互作用蛋白(RIP)激酶依赖性坏死病。然而,在肝炎期间,它导致程序性肝细胞坏死,这与 RIPK3 无关。 MLKL 也参与内涵体运输和细胞外囊泡的形成。
Physical form
在含 0.09% (w/v) 叠氮化钠和 2% 蔗糖的 1x PBS 缓冲液中提供纯化抗体。
Other Notes
合成肽位于以下区域:DVWKELSLLLQVEQRMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNE
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.
Yoon S
Immunity, 47, 51-51 (2017)
MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1? Independently of Gasdermin-D.
Gutierrez KD
Journal of Immunology, 198, 2156-2156 (2017)
The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.
Gunther C
The Journal of Clinical Investigation, 126, 4346-4346 (2016)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB2108746-100UL | 04061836137182 |