Anti-Complement Factor H antibody produced in goat

Complement factor H (CFH) codes for 20 complement-control protein modules (CCPs 1–20). It is expressed in the liver, mesangial cells, endothelial cells and fibroblasts. It is a membrane cofactor protein. The CFH gene is localized on human chromosome 1q31.3.

Peptide with sequence C-HLVPDRKKDQYK from the internal region of the protein sequence according to NP_000177.2.

Complement factor H (CFH) is a negative regulator of the alternative pathway. It suppresses spontaneous complement activation and its response on self surfaces. CFH possesses decay-accelerating activity and destabilizes the C3b amplification in the alternate complement pathway. It also has a role in C3b cleavage by its cofactor activity. The protein has been linked to various diseases like age-related macular degeneration, kidney disorder and C3 glomerulopathy. CFH might prevent complement activation in ischemic renal injury by binding to tubular epithelial cells.

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Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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