biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human, rat
technique(s)
indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DDAH2(23564)
General description
DDAH (Dimethylarginine dimethylaminohydrolase) exists as two isoforms; DDAH1, and DDAH2. Tissues expressing endothelial nitric oxide synthases is predominated by DDAH2.
Immunogen
Peptide with sequence SSLCLVLSTRPHS from the C Terminus of the protein sequence according to NP_039268.1.
Application
Anti-DDAH2 antibody produced in goat is suitable for indirect ELISA and western blot applications.
Biochem/physiol Actions
DDAH2 (Dimethylarginine dimethylaminohydrolase 2) Activity partly determines the cellular concentration of methylarginine. Concentration of ADMA (asymmetrical dimethylarginine) in endothelial cells is increased on the advent of pharmacological inhibition of DDAH, which also leads to the inhibition of NO-mediated endothelium dependent relaxation of blood vessels.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
J M Leiper et al.
The Biochemical journal, 343 Pt 1, 209-214 (1999-09-24)
Methylarginines inhibit nitric oxide synthases (NOS). Cellular concentrations of methylarginines are determined in part by the activity of dimethylarginine dimethylaminohydrolase (DDAH; EC 3.5.3. 18). We have cloned human DDAH and identified and expressed a second novel DDAH isoform (DDAH I
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