Anti-LXR α/LXR β antibody produced in goat

Liver X receptor α and β (LXR-α/LXR-β) are members of LXRs that belong to the nuclear receptor superfamily. LXR-α is expressed predominantly in macrophages, liver, intestine, kidney, lung and adipose tissue. The protein contains a DNA-binding domain that requires the ligand-binding domain to heterodimerize with a retinoid X receptor partner for its DNA-binding activity. The gene encoding this protein is localized on to human chromosome 11p11.2.

Peptide with sequence CRLQDKKLPPLLSEI from the internal region of the protein sequence according to NP_005684; NP_009052.

Liver X receptor α (LXR-α) has an important role in the control of cholesterol homeostasis. LXRs have been found to regulate inflammatory response in macrophages. They are also involved in the regulation of cell proliferation.

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Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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