Anti-PODXL antibody produced in goat

PODXL (podocalyxin like) is an anti-adhesive transmembrane protein which belongs to the sialomucin protein family. It is associated with cancer development and aggressiveness. The protein is expressed in various cells including epithelial cells of kidney glomeruli, vascular endothelial cells, hematopoietic stem cells and platelets. The gene encoding PODXL is localized on human chromosome 7q32.3.

Peptide with sequence C-DNLTKDDLDEEEDTH from the C Terminus of the protein sequence according to NP_001018121.1 ; NP_005388.2.

PODXL (podocalyxin like) acts as an anti-adhesion molecule in kidney open filtration pathways. It interacts with the actin-binding protein ezrin in cancer. Using ezrin and the bridging protein NHERF (Na⁺/H⁺) exchanger regulatory factor, it connects to the cytoskeleton to regulate cytoskeletal-related functions in tumor progression. In human, PODXL stimulates the cell adherence capacity to immobilized ligands and vascular endothelial cells in presence of integrins.

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Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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