Anti-Pyruvate Carboxylase antibody produced in goat

Pyruvate carboxylase (PC), a mitochondrial enzyme, is a nuclear-encoded protein. Expression of biologically active PC is seen in skeletal muscle. PC is a homotetramer in vertebrates, with each subunit having biotin carboxylase (BC), carboxyltransferase (CT), and biotin-carboxyl carrier protein (BCCP) domains and a covalently linked biotin cofactor. The PC gene is located on human chromosome 11q13.2.

Peptide with sequence C-KFKEVKKAYVEANQ from the internal region of the protein sequence according to NP_000911.2; NP_001035806.1; NP_071504.2.

Anti-Pyruvate Carboxylase antibody produced in goat has been used in immunoblotting.

Pyruvate carboxylase (PC) enzyme converts pyruvate to oxaloacetate. It plays an important role in mitochondrial metabolism in all cells and its absence is lethal. Expression of PC is highly essential for the development of pulmonary tumors. PC is involved in the pulmonary tropism of metastatic breast cancer. It is associated with the pathogenesis of ovarian cancer. Lower expression of PC can block cell proliferation, progression of the cell cycle, migration, and invasion of cells.

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Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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