SAB2500845
Anti-Pyruvate Carboxylase antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Anti-PCB
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), WB
Citations:
8
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human, rat, canine, pig, bovine
technique(s)
indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PC(5091)
General description
Pyruvate carboxylase (PC), a mitochondrial enzyme, is a nuclear-encoded protein. Expression of biologically active PC is seen in skeletal muscle. PC is a homotetramer in vertebrates, with each subunit having biotin carboxylase (BC), carboxyltransferase (CT), and biotin-carboxyl carrier protein (BCCP) domains and a covalently linked biotin cofactor. The PC gene is located on human chromosome 11q13.2.
Immunogen
Peptide with sequence C-KFKEVKKAYVEANQ from the internal region of the protein sequence according to NP_000911.2; NP_001035806.1; NP_071504.2.
Application
Anti-Pyruvate Carboxylase antibody produced in goat has been used in immunoblotting.
Biochem/physiol Actions
Pyruvate carboxylase (PC) enzyme converts pyruvate to oxaloacetate. It plays an important role in mitochondrial metabolism in all cells and its absence is lethal. Expression of PC is highly essential for the development of pulmonary tumors. PC is involved in the pulmonary tropism of metastatic breast cancer. It is associated with the pathogenesis of ovarian cancer. Lower expression of PC can block cell proliferation, progression of the cell cycle, migration, and invasion of cells.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Arun Nandwani et al.
Redox biology, 69, 102989-102989 (2023-12-16)
Inspite of exerting independent cellular functions, the endoplasmic-reticulum (ER) and the mitochondria also physically connect at specific sites termed mitochondria-associated ER membranes (MAMs) and these sites consist of several tethering proteins that play varied roles in diverse cellular processes. However
Hongkai Shang et al.
Aging, 12(21), 21874-21889 (2020-11-13)
The aim of this study was to explore prognosis-related biomarkers and underlying mechanisms during ovarian carcinoma progression and development. mRNA expression profiles and GSE49997 dataset were downloaded. Survival analyses were performed for genes with high expression levels. Expression level of
Aparna Shinde et al.
Breast cancer research : BCR, 20(1), 76-76 (2018-07-15)
Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic progression. Disseminated tumor cells encounter major changes in nutrient supplies and oxidative stresses compared to the primary tumor and must demonstrate
Raju Ahmed et al.
Journal of immunological methods, 406, 143-147 (2014-03-25)
Endogenous biotin or biotinylated protein binding activity is a major drawback to biotin-avidin/streptavidin detection system. The avidin/streptavidin conjugate used to detect the complex of the biotinylated secondary antibody and the primary antibody binds to endogenous biotin or biotinylated proteins leading
Ariane D Minet et al.
Biochemical and biophysical research communications, 402(2), 196-197 (2010-09-03)
Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyses the carboxylation of pyruvate to oxaloacetate thereby allowing supplementation of citric acid cycle intermediates. The presence of PC in skeletal muscle is controversial. We report here, that PC protein is easily
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Sigma article discusses tumor cell metabolic pathways, focusing on aerobic glycolysis and mitochondrial activity.
本文介绍了增殖活性细胞为何需要碳源和氮源合成大分子。尽管大部分肿瘤细胞利用有氧糖酵解途径并分流线粒体氧化磷酸化代谢物，但许多肿瘤细胞表现出线粒体活性增加。
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