SAB2501101
Anti-VMAT2/SLC18A2 antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Anti-SLC18A2, Anti-SVAT, Anti-SVMT, Anti-VAT2
产品名称
Anti-VMAT2/SLC18A2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
Quality Level
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC18A2(6571)
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Solute carrier family 18 member A2 (SLC18A2) modulates the release of neurotransmitters like dopamine, serotonin and γ-amino butyric acid. It has a role in the accumulation of neurotransmitters in synaptic vesicles to prevent toxicity. SLC18A2 has been linked to tardive dyskinesia and may be associated with Parkinson′s disease.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Solute carrier family 18 member A2 (SLC18A2) or vesicular monoamine transporter 2 (VMAT2) is a transmembrane protein that acts at nerve terminals. It is expressed in platelets and in central, peripheral and enteric neurons. The gene encoding SLC18A2 consists of 16 exons and is localized on human chromosome 10q25.
Immunogen
Peptide with sequence C-SYPIGEDEESESD from the C Terminus of the protein sequence according to NP_003045.2.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson's disease.
Brighina L
Neurobiology of Aging (2013)
Vesicular monoamine transporter, type 2 (VMAT2) expression as it compares to insulin and pancreatic polypeptide in the head, body and tail of the human pancreas.
Freeby M
Islets (2012)
Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia.
Zai CC
Journal of Psychiatric Research (2013)
Shiliang Zhang et al.
Nature neuroscience, 18(3), 386-392 (2015-02-11)
Mesoaccumbens fibers are thought to co-release dopamine and glutamate. However, the mechanism is unclear, and co-release by mesoaccumbens fibers has not been documented. Using electron microcopy, we found that some mesoaccumbens fibers have vesicular transporters for dopamine (VMAT2) in axon
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