SAB2501441
Anti-MYO5A antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Anti-GS1, Anti-MYH12, Anti-MYO5, Anti-MYR12, Myosin VA (heavy chain 12, myoxin)
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
indirect ELISA
western blot
western blot
Species reactivity:
human, pig, bovine, mouse, rat
Citations:
5
Technique(s):
indirect ELISA: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-MYO5A antibody produced in goat, affinity isolated antibody, buffered aqueous solution
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, pig, bovine, mouse, rat
technique(s)
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MYO5A(4644)
Biochem/physiol Actions
Myosin VA associates with the microtubule-based motors and mediates organelle transport. It associates with Ras-related protein Rab-10 and mediates the glucose transporter type 4 translocation to plasma membrane. Mutations in the myosin VA is implicated in hypopigmentation disorder, Griscelli syndrome (GS1) and Elejalde syndrome.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Myosin VA gene is mapped to human chromosome 15q21.2. It is a two-headed actin-based processive motor protein. Myosin VA comprises two heavy chains. Each chain has N-terminal motor domain, a neck region with six light chains and a coiled-coil and globular domain comprising tail region.
Immunogen
Peptide with sequence ETKQLELDLN, from the internal region of the protein sequence according to NP_000250.3; NP_001135967.1
Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Myosin-V stepping kinetics: a molecular model for processivity
Rief M, et al.
Proceedings of the National Academy of Sciences of the USA, 97(17), 9482-9486 (2000)
Ming Zhang et al.
Oxidative medicine and cellular longevity, 2014, 294150-294150 (2014-05-03)
The disruption of physiologic vascular smooth muscle cell (VSMC) migration initiates atherosclerosis development. The biochemical mechanisms leading to dysfunctional VSMC motility remain unknown. Recently, cytokine BMP-2 has been implicated in various vascular physiologic and pathologic processes. However, whether BMP-2 has
Congenital Hypopigmentary Disorders with Multiorgan Impairment: A Case Report and an Overview on Gray Hair Syndromes
Gironi LC, et al.
Medicina, 55(3), 78-78 (2019)
Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes
Chen Y, et al.
The Journal of cell biology, 198(4), 545-560 (2012)
A D Mehta et al.
Nature, 400(6744), 590-593 (1999-08-17)
Class-V myosins, one of 15 known classes of actin-based molecular motors, have been implicated in several forms of organelle transport, perhaps working with microtubule-based motors such as kinesin. Such movements may require a motor with mechanochemical properties distinct from those
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