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Merck
CN

SAB2701949

抗-ACSL4(C-端) 兔抗

别名:

FACL4, LACS4, MRX63, MRX68

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IF, IHC (p), IP, WB
Citations:
4
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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

liquid

mol wt

74 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable, immunofluorescence: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable, western blot: 500-10000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ACSL4(2182)

Immunogen

与FACL4(Uniprot ID#O60488)的氨基酸649和711中的一个区域对应的合成肽

Application

建议的起始稀释度如下:ICC/IF:1:100-1:1000,免疫组化石蜡切片:1:100-1:1000, IP:1:1000-1:5000,蛋白质印迹:1:500-1:10000。尚未在其他应用中测试。最佳工作稀释度应由最终用户通过实验确定。

Biochem/physiol Actions

该基因编码的蛋白质是长链脂肪酸-辅酶A连接酶家族的同工酶。尽管底物特异性、亚细胞定位和组织分布不同,但该家族的所有同工酶均将游离的长链脂肪酸转化为脂肪酰基辅酶A酯,从而在脂质生物合成和脂肪酸降解中起关键作用。该同工酶优先利用花生四烯酸作为底物。这种酶的缺乏可能导致智力低下或Alport综合征。该基因的可变剪接产生2个转录物变体。[由 RefSeq 提供]

Features and Benefits

完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多信息。

Physical form

1XPBS,20%甘油(pH7)。添加 0.01% 硫柳汞作为防腐剂。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Aquatic Chronic 3 - Skin Sens. 1

存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
低风险生物材料

此项目有



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Dadi Jiang et al.
Nature communications, 15(1), 4114-4114 (2024-05-16)
Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolded protein response (UPR), also determines cellular sensitivity to ferroptosis. Cancer
Zhipeng Li et al.
Nature chemical biology, 18(7), 751-761 (2022-06-01)
The selenoprotein glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid peroxides into nontoxic lipid alcohols. GPX4 has emerged as a promising therapeutic target for cancer treatment, but some cancer cells are resistant to ferroptosis triggered by GPX4 inhibition. Using
Leslie Magtanong et al.
Cell chemical biology, 26(3), 420-432 (2019-01-29)
The initiation and execution of cell death can be regulated by various lipids. How the levels of environmental (exogenous) lipids impact cell death sensitivity is not well understood. We find that exogenous monounsaturated fatty acids (MUFAs) potently inhibit the non-apoptotic



全球贸易项目编号

货号GTIN
SAB2701949-100UL04061837280931