产品名称
单克隆抗- Iba1 小鼠抗, clone GT10312, affinity isolated antibody
biological source
mouse
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
GT10312, monoclonal
form
buffered aqueous solution
mol wt
17kDa
species reactivity
mouse, human, rat
concentration
2.03mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:1000
indirect immunofluorescence: suitable
western blot: 500-3000
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AIF1(199)
Application
小鼠抗-Iba1 单克隆抗体用于：
- 双重免疫荧光法
- 免疫荧光法
- 免疫组化
Biochem/physiol Actions
离子钙结合衔接分子1（IBA1）与纤丝状肌动蛋白（F-肌动蛋白）和 L-丝束蛋白相互作用。受伤期间，其表达受到调节。炎症细胞因子也诱导 IBA1 表达。IBA1 表达与冠状动脉血管病变（CAV）的移植排斥有关。它在肝细胞癌中高表达，或能作为潜在的标志物和治疗靶标。滑液和外周血单核细胞中 AIF1 的表达增加与类风湿关节炎有关。
Disclaimer
除非我们的目录或产品随附的其他公司文档中另有说明，我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人或动物的任何类型的消费或应用。
Features and Benefits
完全放心地评估抗体。如果抗体在您的申请中不起作用，我们将全额退款或发放替代抗体。了解更多。
General description
离子钙结合衔接子分子1（IBA1），又称同种异体移植炎症因子1（AIF1），定位于人类染色体 6p21.33。其编码分子量为 17 kDa的蛋白，包含与钙结合的EF手基序。IBA1 在肺、扁桃体、淋巴结和脾脏中表达。此外，也在巨噬细胞和神经胶质细胞中表达。
Immunogen
包含人 Iba1 中心区域内序列的重组蛋白。
Other Notes
纯化：经蛋白 G 亲和纯化
Physical form
磷酸盐缓冲盐水，不添加防腐剂。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Expression of Allograft Inflammatory Factor-1 (AIF-1) in Hepatocellular Carcinoma
Zhang Q, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24, 6218-6218 (2018)
Expression of allograft inflammatory factor-1 in peripheral blood monocytes and synovial membranes in patients with rheumatoid arthritis
Pawlik A, et al.
Human immunology, 77(1), 131-136 (2016)
Xianliang Zhang et al.
Frontiers in aging neuroscience, 11, 78-78 (2019-04-27)
Recent studies have suggested that exercise may be beneficial for delaying or attenuating Alzheimer's disease (AD). However, the underlying mechanisms were not clear. Microglia-mediated neuroinflammation is suggested to play an important role in the pathology of AD. The present study
Treadmill exercise decreases Abeta deposition and counteracts cognitive decline in APP/PS1 mice, possibly via hippocampal microglia modifications
Zhang X, et al.
Frontiers in Aging Neuroscience, 11, 78-78 (2019)
Structural and functional characterization of human Iba proteins
Schulze JO, et al.
The FEBS journal, 275(18), 4627-4640 (2008)
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