Anti-MTCH2 antibody produced in rabbit

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Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals, suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway.

MTCH2 antibody was raised against a 15 amino acid peptide near the amino terminus of human MTCH2.

The action of this antibody can be blocked using blocking peptide SBP3500013.

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.