产品名称
抗-LAMP-1 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 46 kDa
species reactivity
rat, human, mouse
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LAMP1(3916)
Application
兔抗-LAMP-1抗体可用于免疫印迹分析。
Biochem/physiol Actions
溶酶体相关膜蛋白1（LAMP-1）可作为细胞内的受体。有研究发现它在多种类型癌细胞的胞质中表达，并且可能参与肿瘤侵袭。LAMP-1对于穿孔素运送到溶解颗粒以及这些溶解颗粒的运动至关重要。敲除这种蛋白质可抑制人类自然杀伤细胞的细胞毒性。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
Features and Benefits
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
General description
溶酶体相关膜蛋白1 (LAMP-1)是I型跨膜蛋白，具有短胞质尾，其中含有溶酶体靶向信号。编码该蛋白的基因位于人染色体13q34上。
Immunogen
LAMP-1抗体靶标为靠近人LAMP-1中心的一个15氨基酸肽。
Other Notes
可通过封闭肽SBP3500285阻断此抗体的作用。
Physical form
以含有 0.02% 叠氮化钠的 PBS 形式提供。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Constitutive expression of a COOH-terminal leucine mutant of lysosome-associated membrane protein-1 causes its exclusive localization in low density intracellular vesicles.
Akasaki K
Journal of Biochemistry (2014)
A dynamic network of estrogen receptors
in murine lymphocytes: fine-tuning
the immune response
in murine lymphocytes: fine-tuning
the immune response
Andrea E. Schneider
Journal of Leukocyte Biology (2017)
Monosomy and ring chromosome 13 in a thyroid nodular goiter-do we underestimate its relevance in benign thyroid lesions?
Sendt W
Cancer Genetics (2012)
LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity.
Krzewski K
Blood (2013)
Karolina Gronkowska et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 57(5), 360-378 (2023-09-28)
Cancer cell multidrug resistance induced by paclitaxel contributes to the high failure rates of chemotherapy and relapse of the disease. Several mechanisms have been described that underlie the observed resistance, including the overexpression of ABCB1 (P-glycoprotein), which represents an ATP-binding
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