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Merck
CN

SAB3500306

Anti-Slc22A17 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-BOCT, Anti-BOIT, Anti-Brain-type organic cation transporter, Anti-Solute carrier family 22 member 17

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203

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产品名称

Anti-Slc22A17 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 59 kDa

species reactivity

rat, human, mouse

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: suitable

NCBI accession no.

Q8WUG5

UniProt accession no.

Q8WUG5

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SLC22A17(51310)

相关类别

Biochem/physiol Actions

Slc22A17 expression is associated with important biological processes such as cell differentiation, apoptosis and inflammation. Slc22A17 mediates endocytosis of neutrophil gelatinase-associated lipocalin, a mammalian protein that can bind to bacterial siderophore enterobactin with high affinity.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Slc22A17 gene is also referred to as brain organic cation transporter (BOCT) and is mapped to human chromosome 14q11.2. The encoded protein is predominantly localized to kidney and liver. The Slc22 proteins consists of 12 transmembrane (TM) α-helices with an extended loop (extracellular) between the first and the second transmembrane regions, and a loop (intracellular) between the sixth and the seventh transmembrane regions.

Immunogen

Slc22A17 antibody was raised against a 14 amino acid peptide near the carboxy terminus of the human Slc22A17.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500306.

Physical form

Supplied in PBS with 0.02% sodium azide.

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
465108031

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Biochemical and structural characterization of the interaction between the Siderocalin NGAL/LCN2 and the N-terminal domain of its endocytic receptor SLC22A17.
Martinez A I C, et al.
The Journal of Biological Chemistry (2015)
Josefin A Jacobsson et al.
Genomics, 90(5), 595-609 (2007-08-24)
The solute carrier family 22 (SLC22) is a large family of organic cation and anion transporters. These are transmembrane proteins expressed predominantly in kidneys and liver and mediate the uptake and excretion of environmental toxins, endogenous substances, and drugs from

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Protein-based Drug Transport

Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.

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