SAB3500343
Anti-Bax antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-Bax
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
immunofluorescence
immunoprecipitation (IP)
indirect ELISA
western blot
immunofluorescence
immunoprecipitation (IP)
indirect ELISA
western blot
Species reactivity:
human
Citations:
9
Technique(s):
immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-Bax antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BAX(581)
Physical form
Supplied in PBS with 0.02% sodium azide.
Application
Anti-Bax antibody produced in rabbit has been used in Western blotting.
Biochem/physiol Actions
BCL2 associated X, apoptosis regulator (BAX) forms a heterodimer with B-cell lymphoma 2 (BCL2) and functions as an apoptotic activator. BAX interacts with and increases the opening of the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in the mitochondrial membrane potential and the release of cytochrome c. The expression of BAX gene is regulated by the tumor suppressor p53 and BAX has been shown to be involved in p53-mediated apoptosis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
BCL2 associated X, apoptosis regulator (BAX) is a proapoptotic protein of the B-cell lymphoma 2 (BCL2) protein family. The gene encoding it is localized on human chromosome 19q13.33.
Immunogen
Bax antibody was raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Bax.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500343.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Bcl-2 family proteins and cancer
K W Yip
Oncogene (2008)
Wnt signal transduction pathway and apoptosis: a review
Nives Pecina-Slaus
Cancer Cell International (2010)
HspB8 mediates neuroprotection against OGD/R in N2A cells through the phosphoinositide 3-kinase/Akt pathway
Zhiping Hu
Brain Research (2016)
The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
P N Kelly
Cell Death and Differentiation (2011)
Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy
Huanyin Li
PLoS ONE (2016)
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