产品名称
抗-KLOTHO 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 111 kDa
species reactivity
human, mouse, rat
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KL(9365)
Application
抗-KL兔抗已被用于免疫印迹技术中的一抗。
Biochem/physiol Actions
KL（克洛索）基因也称为抗衰老基因，因为它可编码与衰老相关的分子。它通过充当辅因子或辅受体来调节成纤维细胞生长因子（FGF）23的信号传导。它参与TRPV5（瞬时受体电位阳离子通道亚家族V成员5）的激活，这是一种离子通道，充当葡萄糖醛酸酶的作用。克洛索会影响多种细胞内信号通路，包括p53/p21、cAMP、蛋白激酶C（PKC）和Wnt信号通路。该基因的突变与早衰样表型和寿命缩短相关。该基因的单核苷酸多态性与镰状细胞性贫血患者出现阴茎异常勃起有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
General description
基因KL（克洛索）编码一种与β-葡萄糖苷酶具有同源性的蛋白质。该基因定位于人类染色体13q12。该基因转录物的长度为5.2kb。可变剪接导致两种形式的生成，一种是跨膜形式，别一种是分泌形式。该跨膜蛋白含有1014个氨基酸。
Immunogen
KLOTHO抗体是针对接近人KLOTHO中心的16个氨基酸肽而开发的。
Other Notes
可以使用阻断肽 SBP3500604阻断该抗体的作用。
Physical form
以含有 0.02%叠氮化钠的 PBS 形式提供。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Hong Su et al.
International journal of general medicine, 15, 7885-7893 (2022-10-29)
This study focused on renal arteriosclerosis and aimed to explore the relationship between Klotho and SIRT1 by morphological staining, which will help to provide new ideas for the treatment of renal-aging-related diseases and a theoretical basis for the development of
Agnieszka Olejnik et al.
Journal of cellular and molecular medicine, 24(11), 6448-6458 (2020-04-23)
Restoration of blood flow to ischaemic heart inflicts ischaemia/reperfusion (I/R) injury, which manifests in metabolic and morphological disorders. Klotho is a protein with antioxidative and antiapoptotic activity, and is involved in the regulation of inflammation and fibrosis. The aim of
Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-I?B/NLRP3 Axis.
He, et al.
Journal of Diabetes Research, 2023, 7423661-7423661 (2023)
Chiao-Yin Sun et al.
Genes, 11(9) (2020-09-10)
The Klotho gene functions as an anti-aging gene. A previous klotho-knockout mice study indicated that neither male nor female gametocytes could accomplish the first meiotic division. It suggested that Klotho might regulate cell division. In this study, we determined the
Current understanding of klotho.
Wang Y and Sun Z
Ageing Research Reviews, 8, 43-51 (2009)
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