SAB3500978
抗-ACE2 兔抗
affinity isolated antibody
别名:
Anti-ACEH
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunoblotting
immunofluorescence
immunohistochemistry
immunoblotting
immunofluorescence
immunohistochemistry
Species reactivity:
human
Citations:
5
Technique(s):
ELISA: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
Uniprot accession no.:
产品名称
抗-ACE2 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
ELISA: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ACE2(59272)
Biochem/physiol Actions
血管紧张素转化酶2（ACE2）通过将Ang I转化为Ang1-9来帮助血管紧张素（Ang）的成熟。它也可能在心脏和肾脏的局部肾素-血管紧张素系统（RAS）中起作用。Ace 2作为严重急性呼吸综合征-冠状病毒（SARS-CoV）和新型冠状病毒（SARS-CoV-2）的功能性受体，后者导致2019冠状病毒病（COVID-19）。Ace 2表达降低可能导致心血管疾病。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
General description
血管紧张素转换酶2（ACE2）基因定位于人类染色体Xp22.2。该基因编码膜相关和分泌的酶。Ace 2是血管紧张素转换酶（ACE）的人类同源物，主要存在于内皮细胞上。在人类中，Ace2仅在心脏、肾脏和睾丸中表达。该蛋白质的特征在于N端PD和C端Collectrin样结构域（CLD）。
Immunogen
产生的抗体是针对对应于人ACE2的N端氨基酸的合成肽。
Other Notes
可以使用阻断肽SBP3500978阻断该抗体的作用。
Physical form
以浓度为1 mg/mL含0.02％叠氮化钠的PBS溶液提供。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Jaśmina Bałaban et al.
Nanotechnology, science and applications, 16, 1-18 (2023-01-27)
The experiments aimed to document the presence of the ACE2 receptor on human muscle cells and the effects of the interaction of these cells with the spike protein of the SARS-CoV-2 virus in terms of induction of pro-inflammatory proteins, as
Emily J Sherman et al.
Scientific reports, 11(1), 15900-15900 (2021-08-07)
The membrane protein angiotensin-converting enzyme 2 (ACE2) is a physiologic regulator of the renin-angiotensin system and the cellular receptor for the SARS-CoV-2 virus. Prior studies of ACE2 expression have primarily focused on mRNA abundance, with investigation at the protein level
Bina Lee et al.
Cell reports. Medicine, 5(5), 101570-101570 (2024-05-16)
While an association between Parkinson's disease (PD) and viral infections has been recognized, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on PD progression remains unclear. Here, we demonstrate that SARS-CoV-2 infection heightens the risk of PD using
ACE2 is on the X chromosome: could this explain COVID-19 gender differences?
Esther Culebras et al.
European heart journal (2020-06-25)
M Donoghue et al.
Circulation research, 87(5), E1-E9 (2000-09-02)
ACE2, the first known human homologue of angiotensin-converting enzyme (ACE), was identified from 5' sequencing of a human heart failure ventricle cDNA library. ACE2 has an apparent signal peptide, a single metalloprotease active site, and a transmembrane domain. The metalloprotease
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