SAB4200020
Anti-TES antibody ,Mouse monoclonal
clone TES75, purified from hybridoma cell culture
别名:
Anti-TESS, Anti-TESS-2, Anti-Testin, Anti-Testis derived transcript
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
TES75, monoclonal
Conjugate:
unconjugated
Application:
WB
Citations:
4
antibody product type
primary antibodies
clone
TES75, monoclonal
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
form
buffered aqueous solution
mol wt
antigen ~48 kDa
species reactivity
bovine, mouse, human, monkey
packaging
antibody small pack of 25 μL
concentration
~1.5 mg/mL
technique(s)
western blot: 0.5-1.0 μg/mL using whole extract of mouse thymus
isotype
IgG3
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TES(26136)
mouse ... Tes(21753)
General description
Monoclonal Anti-TES (mouse IgG3 isotype) is derived from the hybridoma TES75 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Testin LIM domain protein (TES) comprises cysteine-rich zinc-binding motifs called LIM domains and is a component of focal adhesions. TES gene is mapped to a common fragile site on chromosome 7q31.2 is designated as FRA7G.
Application
Anti-TES antibody, mouse monoclonal may be used in immunoblotting.
Biochem/physiol Actions
Monoclonal Anti-TES recognizes human, monkey, bovine, and mouse TES
Testin LIM domain protein (TES), a putative tumor-suppressor gene, is essential for motility and is key for the tumor cell anchorage and metastasis. TES mRNA expression is found in several cancer-derived cell lines, particularly hematopoietic, breast and ovarian cancer cell lines as well as in primary tumors. This was correlated with methylation of TES CpG island. Furthermore, TES gene knockout revealed its role as a tumor suppressor gene as well as in actin stress fibre organization.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Characterization of the human TESTIN gene localized in the FRA7G region at 7q31. 2
Tatarelli C, et al.
Genomics, 68(1), 1-12 (2000)
Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene
Chene L, et al.
International Journal of Cancer. Journal International Du Cancer, 111(5), 798-804 (2004)
TES is a novel focal adhesion protein with a role in cell spreading
Coutts AS, et al.
Journal of Cell Science, 116(5), 897-906 (2003)
Prognostic relevance of the expressions of CAV1 and TES genes on 7q31 in melanoma
Laura V, et al.
Frontiers in Bioscience, 4(1), 1802-1812 (2012)
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