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Merck
CN

SAB4200050

Anti-SRGAP3 antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

Anti-Wave-associated rac GTPase-activating protein , Anti-ARHGAP14, Anti-MEGAP, Anti-Mental disorder-associated gap protein, Anti-SLIT-ROBO GAP 3, Anti-SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3), Anti-WRP

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203

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产品名称

Anti-SRGAP3 antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~124 kDa

species reactivity

human, mouse

packaging

antibody small pack of 25 μL

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 1.5-3 μg/mL using mouse brain extracts (S1 fraction) and HEK-293T cell lysates overexpressing SRGAP3

UniProt accession no.

O95747

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... OXSR1(9901)

相关类别

Application

Anti-SRGAP3 antibody produced in rabbit has been used in immunofluorescence and immunoblotting.

Biochem/physiol Actions

SRGAP3 (Slit-ROBO Rho GTPase-activating protein 3) negatively regulates cell migration, by inhibiting the activity of Rac1 and Cdc42. SRGAP3/MEGAP has been associated with severe mental retardation in several patients. It plays pivotal roles in learning and memory. SRGAP3/WRP interacts directly to WAVE-1 through its Src homology domain and specifically inhibits Rac function in vivo.Induced expression of SRGAP3 inhibits Rac1 and Cdc42 activity and impedes cell migration by impairing actin and microtubule dynamics and formation of focal complexes.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Anti-SRGAP3 is produced in rabbit using as the immunogen a synthetic peptide corresponding to a fragment of human SRGAP3 (GeneID: 9901), conjugated to KLH. SRGAP3 (Slit-ROBO Rho GTPase-activating protein 3, also known as MEGAP, is a GTPase activating protein, that belongs to the Slit-ROBO GAPs (SRGAPs) family. It is predominantly expressed in the brain during embryonic development and in the adult brain, specifically in neurons of the hippocampus and cortex. SRGAP3 exists as two isoforms SRGAP3A and SRGAP3B.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
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分析证书(COA)

Lot/Batch Number
119K4829

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Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway
Wong K, et al.
Cell, 107(2), 209-221 (2001)
MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation
Yang Y, et al.
Experimental Cell Research, 312(12), 2379-2393 (2006)
SrGAP3 interacts with lamellipodin at the cell membrane and regulates Rac-dependent cellular protrusions
Endris V, et al.
Journal of Cell Science, 124(23), 3941-3955 (2011)
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling
Soderling SH, et al.
Nature Cell Biology, 4(12), 970-970 (2002)

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