产品名称
Anti-PSPC1 (C-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~45 kDa
antigen ~59 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells
indirect immunofluorescence: 1.25-2.5 μg/mL using paraformaldehyde fixed HEK-293T cells
western blot: 0.5-1 μg/mL using lysates of HEK-293T cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PSPC1(55269)
mouse ... Pspc1(66645)
rat ... Pspc1(305910)
Application
Anti-PSPC1 (C-terminal) antibody produced in rabbit has been used in:
- immunoblotting
- ribonucleoprotein immunoprecipitation assay
- immunofluorescence
- immunocytochemistry
Biochem/physiol Actions
Paraspeckle component 1 (PSPC1) is involved in the regulation of nuclear receptors such as the progesterone receptor and the thyroid receptor and in a wide range of processes such as splicing and RNA metabolism.
Since paraspeckle component 1 (PSPC1) has lower background nucleoplasmic signal in various cell types compared to other members of DBHS (drosophila behavior human splicing) family of proteins, it is frequently used as a marker for paraspeckles. The encoded protein plays a vital role in regulation of transcription. Deletion of the gene is associated with the hindered psychomotor development, muscle hypotonia, unilateral microphtalmia with ptosis, congenital eye malformation and facial dysmorphic features.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
PSPC1 has two isoforms α and β.
Paraspeckle component 1 (PSPC1) is encoded by the gene mapped to human chromosome 13q12.11. The encoded protein is a member of DBHS (Drosophila Behavior Human Splicing) family of proteins.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
PSF and p54nrb/NonO-multi-functional nuclear proteins
Shav-Tal Y and Zipori D
Febs Letters, 531(2), 109-114 (2002)
The Hepatitis Delta Virus accumulation requires paraspeckle components and affects NEAT1 level and PSP1 localization
Beeharry Y, et al.
Scientific Reports, 8(1), 6031-6031 (2018)
Paraspeckles
Fox A H
Cold Spring Harbor Perspectives in Biology, 2 (2010)
AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis
Xu K, et al.
Biology of Reproduction, 90(6), 119-111 (2014)
Yasnee Beeharry et al.
Scientific reports, 8(1), 6031-6031 (2018-04-18)
The Hepatitis Delta Virus (HDV) relies mainly on host proteins for its replication. We previously identified that PSF and p54nrb associate with the HDV RNA genome during viral replication. Together with PSP1, these proteins are part of paraspeckles, which are
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